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Symptom Clusters in Hemodialysis : Insights From a Multicenter Analysis Using Tetrachoric Correlations

NCT07465042 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 256

Last updated 2026-03-11

No results posted yet for this study

Summary

In 2025, Guerraoui et al. published the Concordance Study in Clinical Kidney Journal, a large multicenter cross-sectional study embedded within the French REIN registry. This study compared symptoms reported by hemodialysis patients using the Dialysis Symptom Index (DSI) with clinician-perceived symptoms, revealing a high symptom burden and marked patient-clinician discordance \[3\].

The present work is a secondary analysis of the Concordance Study dataset. Building on the original findings, this analysis aims to deepen understanding of symptom organization and determinants in hemodialysis using multivariate and correlation-based approaches. Specifically, our objectives were :

1. to identify and characterize symptom clusters using tetrachoric correlations and hierarchical clustering;
2. to examine associations between symptoms (and clusters) and comorbidity burden, while assessing potential sex-specific patterns in symptom expression.

Through this secondary analysis, we aim to clarify the internal architecture of symptom co-occurrence, identify key demographic drivers such as sex, and generate evidence supporting cluster-informed, individualized approaches to symptom assessment and management in routine nephrology care.

Conditions

  • DIALYSIS SYMPTOMS AND ANXIETY
  • Hemodialysis

Interventions

OTHER

observational cross sectional study

no intervention : observational

Sponsors & Collaborators

  • Calydial

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-01-01
Primary Completion
2023-01-01
Completion
2024-12-31

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07465042 on ClinicalTrials.gov