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Topical Minocycline for CARP

NCT07462702 · Status: NOT_YET_RECRUITING · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 35

Last updated 2026-07-21

No results posted yet for this study

Summary

This proof-of-concept trial evaluates the efficacy, safety, and patient satisfaction of topical minocycline foam (AMZEEQ®) in patients aged 9 and older with confluent and reticulated papillomatosis (CARP). Participants will apply AMZEEQ® to one side of the body and a topical emollient to the other for 5 weeks, followed by an optional extension period. The study aims to assess whether topical minocycline is a well-tolerated and effective alternative to oral antibiotics.

Conditions

  • Confluent and Reticulated Papillomatosis (CARP)

Interventions

DRUG

Topical Minocycline Foam FXFM244

Topical minocycline foam that will be applied to half of the subject's body that will be chosen by the subject.

OTHER

Control

Control topical emollient that will be applied to the contralateral half of the body.

Sponsors & Collaborators

Principal Investigators

  • Lara Wine Lee, MD · Medical University of South Carolina

Study Design

Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
9 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-09-15
Primary Completion
2027-08-31
Completion
2028-02-29
FDA Drug
Yes

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07462702 on ClinicalTrials.gov