Memory Enhancement in Aging With Optimal Dosing

Summary

This project optimizes high-resolution transcranial Alternating Current Stimulation (tACS) to improve memory in healthy older adults, advancing drug-free approaches for Alzheimer's disease and related dementia (ADRD). We test stimulation schedules and develop an adaptive, brain-guided tACS system to strengthen memory-supporting networks.

Conditions

• Aging
• Noninvasive Brain Stimulation
• Memory

Interventions

DEVICE

1-day patterned tACS

Device: High definition transcranial electrical current stimulation Low-intensity, noninvasive application of electrical current to the human scalp with the goal of modulating levels of neuronal excitability.

DEVICE

3-day patterned tACS

Device: High definition transcranial electrical current stimulation Low-intensity, noninvasive application of electrical current to the human scalp with the goal of modulating levels of neuronal excitability.

DEVICE

5-day patterned tACS

Device: High definition transcranial electrical current stimulation Low-intensity, noninvasive application of electrical current to the human scalp with the goal of modulating levels of neuronal excitability.

DEVICE

1-day continuous tACS

Device: High definition transcranial electrical current stimulation Low-intensity, noninvasive application of electrical current to the human scalp with the goal of modulating levels of neuronal excitability.

DEVICE

3-day continuous tACS

Device: High definition transcranial electrical current stimulation Low-intensity, noninvasive application of electrical current to the human scalp with the goal of modulating levels of neuronal excitability.

DEVICE

5-day continuous tACS

Device: High definition transcranial electrical current stimulation Low-intensity, noninvasive application of electrical current to the human scalp with the goal of modulating levels of neuronal excitability.

Sponsors & Collaborators

• Boston University Charles River Campus

  lead OTHER

Principal Investigators

• Robert Reinhart, PhD · Boston University Charles River Campus

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Model

CROSSOVER

Eligibility

Min Age

65 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2026-06-01

Primary Completion

2031-01-31

Completion

2031-01-31

FDA Device

Yes

Countries

• United States

Study Locations