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International Multi-center Profile of Emergency Large-Bowel Obstruction Management and Outcomes

NCT07458867 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 500

Last updated 2026-03-09

No results posted yet for this study

Summary

Mechanical large-bowel obstruction is a common and high-risk emergency surgical condition with substantial variation in diagnostic evaluation, operative timing, and management strategies across institutions and healthcare systems. Evidence guiding optimal management remains limited and is largely derived from retrospective or single-center studies.

IMPEL is an international, multicenter, time-bound, prospective observational cohort study designed to characterize real-world presentation, diagnostic pathways, operative and non-operative management, and short-term outcomes in adults presenting with mechanical large-bowel obstruction. By capturing standardized patient-level, radiologic, operative, and outcome data across diverse acute care settings, IMPEL aims to describe contemporary practice patterns, quantify variation in care, and identify factors associated with morbidity, mortality, and stoma-related outcomes.

Conditions

  • Large Bowel Obstruction

Sponsors & Collaborators

  • Association of Surgeons of Great Britain and Ireland

    collaborator UNKNOWN

  • European Society of Coloproctology

    collaborator UNKNOWN

  • American Society of Colon and Rectal Surgeons

    collaborator OTHER

  • University of Pennsylvania

    collaborator OTHER

  • European Society for Trauma and Emergency Surgery

    lead OTHER

Principal Investigators

  • Gary A Bass, MD, PhD · University of Pennsylvania

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-07-01
Primary Completion
2027-06-30
Completion
2027-07-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07458867 on ClinicalTrials.gov