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Cardiac Morphology and Function in Individuals With Autonomic Dysreflexia

NCT07456722 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 48

Last updated 2026-03-11

No results posted yet for this study

Summary

This case-control study aims to investigate left ventricular remodeling in individuals with chronic spinal cord injury or disease (SCI/D) (≥10 years) and autonomic dysreflexia (AD) who have no prior cardiovascular history. The primary objective is to compare cardiac changes between 24 individuals with high-level SCI/D (above Th6) who have AD and 24 individuals with low-level SCI/D (below Th10) who do not have AD. A secondary objective examines how factors such as age, sex, injury duration, and physical activity are associated with cardiac remodeling.

All 48 participants will undergo cardiac MRI as well as blood measurement of B-type natriuretic peptid to assess cardiac morphology and function. The findings could shed light on a potentially underestimated cardiovascular risk factor in the SCI/D population.

Conditions

  • Autonomic Dysreflexia
  • Spinal Cord Injuries and Disorders (SCI/D)
  • Cardiac Remodeling

Sponsors & Collaborators

  • Swiss Paraplegic Research, Nottwil

    lead NETWORK

Principal Investigators

  • Jens Wöllner, Prof. Dr. med. · Swiss Paraplegic Centre

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-05-01
Primary Completion
2028-07-31
Completion
2028-10-31

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07456722 on ClinicalTrials.gov