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Examine Impact of Topical Application of Active Versus Placebo on the Skin Microbiome in Sensitive Skin.

NCT07454525 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 45

Last updated 2026-03-06

No results posted yet for this study

Summary

The purpose of this study is to build insights to understand how the placebo and active impacts the skin microbiome in women with high skin sensitivity (SS10 \> 13) and sun exposure. Microbiome samples will be taken at baseline after 2 weeks of using the placebo (base without active) as a run-in period followed by the usage of placebo for an additional 4 weeks. The participants will then start the usage of active formula for an additional 8 weeks with microbiome samples collected at the 10-week and 14-week. This will allow us to observe how the microbiome changes over time after the product usage of both placebo and active formulations relative to the pre-regimen condition. In addition, headshot photos will be taken using the Haut AI application at each time point concurrent to the microbiome sample collection to examine changes in skin appearances after the regimen.

Conditions

  • Skin
  • Skin Microbiome
  • Skin Microbiota
  • Skin Ageing

Interventions

OTHER

Active Cream

Active facial cream with postbiotics from Bifidobacterium and Pediococcus genera. Product will be applied to the face twice a day in the morning and evening

OTHER

Placebo Cream without active substance

Placebo facial cream without postbiotics with same other ingredients as active product. Product will be applied to the face twice a day in the morning and evening

Sponsors & Collaborators

  • Hellobiome

    collaborator UNKNOWN

  • Kaneka Americas Holding Inc.

    collaborator INDUSTRY

  • AB Biotics, SA

    lead INDUSTRY

Study Design

Allocation
NA
Purpose
PREVENTION
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
40 Years
Max Age
60 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-02-28
Primary Completion
2026-04-30
Completion
2026-06-30

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07454525 on ClinicalTrials.gov