MedTrace Logo

Prospective Observational Study of Exhaled Carbon MonoxideTrajectories and Outcomes in ICU Patients

NCT07454057 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 220

Last updated 2026-03-06

No results posted yet for this study

Summary

This is a single-center, prospective, observational study in adult intensive care unit (ICU) patients. The study will measure exhaled carbon monoxide (eCO) once daily for up to 7 days after ICU admission using a red blood cell lifespan breath analyzer, which simultaneously estimates erythrocyte lifespan. eCO is a gas produced endogenously during heme degradation and may reflect hemolysis, oxidative stress, and inflammation in critically ill patients.

The purpose of this study is to describe how eCO changes over time in ICU patients and to determine whether different eCO patterns are associated with clinical outcomes. The primary outcome is all-cause mortality within 28 days after enrollment. Secondary outcomes include 90-day mortality, acute kidney injury, organ dysfunction assessed by SOFA score, transfusion requirement, changes in anemia-related indices, ICU length of stay, and duration of invasive mechanical ventilation. Participation does not change routine clinical care; study procedures involve breath sampling and collection of clinical data from the medical record.

Conditions

  • Critical Illness； Intensive Care Unit Patients

Sponsors & Collaborators

  • Shanghai Zhongshan Hospital

    lead OTHER

Principal Investigators

  • Ming Zhong · Fudan University

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-03-15
Primary Completion
2027-08-30
Completion
2027-11-30

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07454057 on ClinicalTrials.gov