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Identification of Possible Trigeminal Neuralgia

NCT07453511 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 250

Last updated 2026-03-23

No results posted yet for this study

Summary

Trigeminal neuralgia (TN) is a severe type of non-dental orofacial pain that can feel like sudden electric shocks in the face and is often mistaken for tooth pain or other dental problems. This can lead to delays in referral and unnecessary, sometimes irreversible, dental treatment. The goal of this observational study is to evaluate how well a new questionnaire (IDentification of possible Trigeminal Neuralgia - IDTN) identifies adults with possible trigeminal neuralgia among patients attending hospital clinics with orofacial pain, with the aim of supporting its use in dental and general medical practice to improve early recognition and referral.

The main questions it aims to answer are:

* How accurately does the IDTN questionnaire identify patients with possible trigeminal neuralgia compared with the specialist clinical diagnosis?
* Which combination of questionnaire items best supports a practical screening score for use in dental and/or general medical practice?

Participants will:

1. Complete the IDTN questionnaire before their clinical appointment (either electronically or on paper)
2. Undergo their usual specialist clinical assessment, during which the final diagnosis will be recorded
3. Allow the research team to compare questionnaire responses with the specialist diagnosis (the reference standard)

A subset of participants will also be asked to complete the questionnaire again a few days later to assess test-retest reliability.

Conditions

  • Trigeminal Neuralgia (TN)
  • Orofacial Pain
  • Dental Pain
  • Questionnaire

Interventions

OTHER

Completion of the IDTN Questionnaire

There are no interventions because this is an observational validation study. Participants complete a 15-item trigeminal neuralgia screening questionnaire (IDTN) before their clinical appointment.

Sponsors & Collaborators

  • British Pain Society

    collaborator UNKNOWN

  • University College, London

    lead OTHER

Principal Investigators

  • Joanna M Zakrzewska · University College London (UCL) and University College London Hospitals NHS Foundation Trust (UCLH)

  • Nikolaos Apostolidis · University College London Hospitals NHS Foundation Trust (UCLH) and University College London (UCL)

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-04-30
Primary Completion
2027-04-30
Completion
2027-05-31

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07453511 on ClinicalTrials.gov