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Transcranial Direct Current Stimulation (tDCS) in Different Psychiatric Disorders

NCT07452835 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 320

Last updated 2026-03-06

No results posted yet for this study

Summary

The goal of this clinical trial is to evaluate the efficacy and safety of transcranial direct current stimulation (tDCS) in reducing core symptoms of different psychiatric disorders using validated clinical scales.

* To assess response and remission rates.
* To evaluate the durability of treatment effects over follow-up.
* To examine effects on cognition, daily functioning, and quality of life.
* To monitor tolerability and adverse events.

Conditions

  • Major Depressive Disorder (MDD)
  • SCHIZOPHRENIA 1 (Disorder)
  • Obsessive-Compulsive Disorder
  • Generalized Anxiety Disorder
  • Insomnia

Interventions

DEVICE

tDCS Parameters

Preparation: * Clean scalp with alcohol to reduce impedance. * Apply conductive gel and position electrodes using the 10-20 EEG system. * Use rubber electrodes (5×7 cm) for anodal/cathodal placement. Stimulation: Ramp-up current over 30 sec to avoid discomfort. Monitor for adverse effects (tingling, itching, headache ). Post-Stimulation Assessment: * Evaluate symptom changes using standardized scales (e.g., HAM-D for depression, Y-BOCS for OCD). * Repeat sessions 3-5 times per week.. Safety and Monitoring Adverse Effects: Mild skin irritation, headache (rarely seizures-screen high-risk patients(. Contraindications: Metallic implants, scalp lesions, epilepsy history. Conclusion tDCS is a promising neuromodulatory tool for psychiatric disorders, with varying protocols based on disorder-specific neural targets.

Sponsors & Collaborators

  • Menoufia University

    lead OTHER

Principal Investigators

  • Mohamed Elbahy · faculty of medicine

  • Mahmoud Abo Salem · faculty of medicine

Study Design

Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
16 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-01-01
Primary Completion
2025-06-30
Completion
2025-06-30

Countries

  • Egypt

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07452835 on ClinicalTrials.gov