MedTrace Logo

The Impact of Saline Temperature and Local Anesthetic Adjuvants on Postoperative Shoulder Pain and Inflammatory Marker Levels Following Laparoscopic Cholecystectomy

NCT07450781 · Status: ENROLLING_BY_INVITATION · Phase: NA · Type: INTERVENTIONAL · Enrollment: 216

Last updated 2026-03-17

No results posted yet for this study

Summary

Laparoscopic cholecystectomy has become the gold standard for the operative treatment of gallbladder disease due to its minimally invasive nature and improved patient outcomes. However, postoperative pain remains a significant concern following this procedure, affecting patient comfort, recovery, potential for same day discharge and overall satisfaction. However, visceral pain, port-site pain, and referred shoulder pain are occasionally reported in laparoscopic cholecystectomy patients . Postoperative shoulder pain is a common complication following laparoscopic cholecystectomy, often attributed to diaphragmatic irritation.

Conditions

  • Shoulder Pain , Laparoscopic Cholecystectomy

Interventions

OTHER

Room-temperature saline (25-30 ml/kg ) irrigation without local anesthetic.

Room-temperature saline (25-30 ml/kg ) irrigation without local anesthetic.

OTHER

Room-temperature saline (25-30 ml/kg l) with local anesthetic ( 0.25% bupivacaine according to body weight).

Room-temperature saline (25-30 ml/kg l) with local anesthetic ( 0.25% bupivacaine according to body weight).

OTHER

Warm saline (37°C, 25-30 ml/kg ) irrigation without local anesthetic.

Warm saline (37°C, 25-30 ml/kg ) irrigation without local anesthetic.

OTHER

Warm saline (37°C, 25-30 ml/kg) with local anesthetic (0.25% bupivacaine).

Warm saline (37°C, 25-30 ml/kg) with local anesthetic (0.25% bupivacaine).

OTHER

No saline irrigation.

No saline irrigation.

OTHER

No saline irrigation but with local anesthetic (local anesthetic instillation at trocar sites).

No saline irrigation but with local anesthetic (local anesthetic instillation at trocar sites).

Sponsors & Collaborators

  • Alexandria University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
HEALTH_SERVICES_RESEARCH
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-02-01
Primary Completion
2026-08-01
Completion
2027-08-01

Countries

  • Egypt

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07450781 on ClinicalTrials.gov