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Effect of Striatal Temporal Interference Stimulation on Language Processing in Neurodegenerative Diseases

NCT07449117 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 70

Last updated 2026-03-04

No results posted yet for this study

Summary

The purpose of this study is to investigate the immediate effects of non-invasive temporal interference stimulation (TIS) targeting the striatum on sentence processing and brain connectivity in patients with neurodegenerative diseases.

Conditions

  • Mild Cognitive Impairment (MCI) Amnestic
  • Lewy Body Disease With Mild Cognitive Impairment
  • Parkinson's Disease With Mild Cognitive Impairment

Interventions

DEVICE

Active Temporal Interference Stimulation (TIS)

Non-invasive brain interference stimulation applied for approximately 20 minutes while the participant performs a sentence comprehension task.

DEVICE

Placebo / Sham TIS

Placebo stimulation applied for approximately 20 minutes while the participant performs a sentence comprehension task.

Sponsors & Collaborators

  • Masaryk University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
60 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-03-31
Primary Completion
2027-12-31
Completion
2028-12-31

Countries

  • Czechia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07449117 on ClinicalTrials.gov