A Study to Evaluate the Effect of AZD6793 on the Pharmacokinetics and Pharmacodynamics of Metformin in Participants With Type 2 Diabetes Mellitus
NCT07433062 · Status: SUSPENDED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 28
Last updated 2026-04-22
Summary
The purpose of this study is to examine the effect of AZD6793 on the Pharmacokinetics and Pharmacodynamics of Metformin in Participants with Type 2 Diabetes Mellitus.
Conditions
Interventions
- DRUG
-
AZD6793
Participants will receive oral doses of metformin with an interval of 12 hours between doses. The morning doses of metformin will be administered together with AZD6793 (Treatment A).
- DRUG
-
AZD6793 Placebo
Participants will receive oral doses of metformin with an interval of 12 hours between doses. The morning doses of metformin will be administered together with AZD6793 placebo (Treatment B).
Sponsors & Collaborators
- lead INDUSTRY
Study Design
- Allocation
- RANDOMIZED
- Purpose
- OTHER
- Masking
- TRIPLE
- Model
- CROSSOVER
Eligibility
- Min Age
- 18 Years
- Max Age
- 70 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2026-01-14
- Primary Completion
- 2026-06-18
- Completion
- 2026-06-18
Countries
- Germany
Study Locations
More Related Trials
-
A Study in Healthy People to Test Whether BI 764198 Influences the Amount of Metformin in the Body
NCT07368569 ·Status: COMPLETED ·Phase: PHASE1
-
A Pharmacokinetic Study of MK-0941 After Multiple Daily Doses in Subjects With Type 2 Diabetes (MK-0941-012)(COMPLETED)
NCT00873821 ·Status: COMPLETED ·Phase: PHASE1
-
A Study in Healthy Men to Test Whether BI 1815368 Influences the Amount of Metformin in the Body
NCT06655220 ·Status: COMPLETED ·Phase: PHASE1
-
Single-centre, Randomised, Double-blind, Placebo-controlled, Four-way Crossover Clinical Study to Investigate Safety and Tolerability and Pharmacokinetics of Single Doses of CM3.1-AC100 in Patients With Type 2 Diabetes
NCT01196728 ·Status: COMPLETED ·Phase: PHASE1
-
A Study to Evaluate the Safety and Pharmacokinetics of Dapagliflozin, Linagliptin, and Metformin in Healthy Adults
NCT07034781 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1
-
Pharmacokinetics, Pharmacodynamics and Safety of Biphasic Insulin Aspart 30 in Type 2 Diabetes
NCT01697618 ·Status: COMPLETED ·Phase: PHASE2
-
Metformin and Molecular Aging in Prediabetes
NCT07302932 ·Status: COMPLETED ·Phase: NA
-
Efficacy and Safety of Biphasic Insulin Aspart 30 in Combination With Metformin in Type 2 Diabetes
NCT00619697 ·Status: COMPLETED ·Phase: PHASE4
-
A Multiple Dose Investigational Drug Study in Patients With Type 2 Diabetes (MK-0941-005)
NCT00511667 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of GSK256073 in Subjects With Type 2 Diabetes Mellitus Who Are Being Treated With Metformin
NCT01376323 ·Status: COMPLETED ·Phase: PHASE2
-
Safety and Efficacy of INCB013739 Plus Metformin Compared to Metformin Alone on Glycemic Control in Type 2 Diabetics
NCT00698230 ·Status: COMPLETED ·Phase: PHASE2
-
PK and Relative Bioavailability of Novel Liquid Metformin vs Tablets
NCT07300020 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1
-
Study to Learn More About Outcomes Reported by Patients Suffering From Type 2 Diabetes Using a Digital Data Collection Tool
NCT04383041 ·Status: COMPLETED
-
A Study to Assess the Food Effect on Bioavailability of Metformin/Gliclazide in Healthy Participants
NCT03467971 ·Status: COMPLETED ·Phase: PHASE1
-
4-Week, Multiple-dose, Dose-escalating Study In Patients With Type 2 Diabetes
NCT03538743 ·Status: COMPLETED ·Phase: PHASE1
-
Bioequivalence Study of Liquid Metformin (100 and 250 mg/mL) vs IR Tablets
NCT07300033 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1
-
A Study to Evaluate the Pharmacokinetics and Safety of BR3409 and Co-administration of BR3409-1 and BR3409-2 in Healthy Volunteers Under Fed Conditions
NCT06879132 ·Status: COMPLETED ·Phase: PHASE1
-
A Study Comparing the Amount of Metformin and After Taking a Combination Tablet vs. Separate Tablets
NCT01055691 ·Status: COMPLETED ·Phase: PHASE1
-
A Drug Interaction Study to Evaluate the Pharmacokinetics of ASP015K and Metformin
NCT02760342 ·Status: COMPLETED ·Phase: PHASE1
-
Safety and Tolerability, Efficacy, Pharmacokinetic and Pharmacodynamic Study of Three Doses of BI 187004 Over 28 Days in Patients With Type 2 Diabetes Mellitus With and Without Metformin
NCT02150824 ·Status: COMPLETED ·Phase: PHASE2
-
Pharmacokinetics of Mitiglinide and Metformin in Free Combination and Fixed-dose Combination in Healthy Male Subjects.
NCT01443221 ·Status: COMPLETED ·Phase: PHASE1
-
Metformin's Effect on Glucagon-induced Glucose Production and Protein Metabolism.
NCT01956929 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of the Safety and Efficacy of MK-3577 in Participants With Type 2 Diabetes Mellitus (MK-3577-009)
NCT00868790 ·Status: TERMINATED ·Phase: PHASE2
-
Short-Term Glycemic Effects of Liquid Metformin vs Standard Tablets
NCT07300059 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1
-
Study Evaluating Safety, Tolerability, And Action Of OAP-189 In Subjects With Type 2 Diabetes On Metformin
NCT00970593 ·Status: COMPLETED ·Phase: PHASE1