Menopausal Impact of Opportunistic Salpingectomy for Ovarian Cancer Prevention

Summary

The goal of this clinical trial is to find out whether removing the fallopian tubes at the time of hysterectomy leads to an earlier menopause. The study includes women under 55 years of age who previously underwent hysterectomy as participants in the HOPPSA trial, where they were randomly assigned to either removal of the fallopian tubes or no removal.

The main question is:

• Does removing the fallopian tubes at the time of hysterectomy lead to an earlier menopause? Researchers will compare women who had their fallopian tubes removed during hysterectomy with women who had hysterectomy alone to see whether menopause occurs earlier after tube removal. Age at menopause will be estimated by measuring follicle-stimulating hormone (FSH) in small blood samples collected on a paper card.

Participants will:

* Collect 4-5 drops of blood using a finger prick
* Place the drops on a paper card and mail it to the researchers
* Complete an online questionnaire These steps will be done twice, one year apart.

Conditions

• Menopause
• Opportunistic Salpingectomy

Interventions

PROCEDURE

Opportunistic salpingectomy

Removal of the fallopian tubes at the time of hysterectomy

Sponsors & Collaborators

• Uppsala University

  collaborator OTHER

• Karolinska Institutet

  collaborator OTHER

• Örebro University, Sweden

  collaborator OTHER

• Queen Mary University of London

  collaborator OTHER

• Region Västerbotten

  collaborator OTHER_GOV

• Göteborg University

  collaborator OTHER

• Umeå University

  lead OTHER

Principal Investigators

• Annika Idahl, MD, PhD, Professor · Umeå University

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Model

PARALLEL

Eligibility

Min Age

20 Years

Max Age

65 Years

Sex

FEMALE

Healthy Volunteers

No

Timeline & Regulatory

Start

2026-03-31

Primary Completion

2029-02-28

Completion

2057-12-31

Countries

• Sweden

Study Locations