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Non-Conventional Microbiological Methods in the Diagnosis of Candidemia

NCT07422155 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 2

Last updated 2026-02-19

No results posted yet for this study

Summary

This study evaluates the diagnostic value of non-conventional microbiological methods for early detection of candidemia and invasive candidiasis in adult hospitalized patients with suspected invasive fungal infection. Conventional blood culture remains the gold standard for diagnosis but has limited sensitivity and may delay initiation of targeted antifungal therapy.

The study investigates whether the combined use of serum biomarkers (1,3)-β-D-glucan, mannan and anti-mannan antibodies, and molecular detection of Candida DNA by PCR improves the diagnostic performance compared with conventional culture-based methods.

In addition, the study explores the host cytokine response associated with different Candida species and other fungal pathogens. The goal is to support the development of an optimized diagnostic algorithm for invasive fungal disease and improve clinical management of critically ill patients.

Conditions

  • Candidemia
  • Invasive Candidiasis

Interventions

DIAGNOSTIC_TEST

Candida Diagnostic Testing Panel

Participants underwent routine blood culture testing for bacteria and fungi and additional non-conventional diagnostic testing for suspected invasive candidiasis, including serum (1,3)-beta-D-glucan, mannan antigen, anti-mannan antibodies, and PCR-based detection of Candida DNA from EDTA whole blood samples. The combined diagnostic panel was used to assess its potential value for earlier and improved detection of candidemia compared with conventional culture-based methods.

Sponsors & Collaborators

  • Institute of Oncology Ljubljana

    lead OTHER

Study Design

Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-01-31
Primary Completion
2018-12-31
Completion
2018-12-31

Countries

  • Slovenia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07422155 on ClinicalTrials.gov