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Prospective Twin Pregnancy Cohort at Montpellier University Hospital

NCT07408973 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 360

Last updated 2026-02-13

No results posted yet for this study

Summary

This prospective observational cohort study aims to investigate the impact of the maternal and early-life exposome on neonatal and early childhood health outcomes in twin pregnancies followed at University Hospital of Montpellier (France). Grounded in the Developmental Origins of Health and Disease (DOHaD) framework, the study focuses on how environmental, biological, and lifestyle exposures during pregnancy and the first year of life influence fetal growth, neonatal health, and early development.

A total of 120 women with monochorionic or dichorionic twin pregnancies and their 240 children will be included. Maternal exposome assessment includes air pollution exposure, lifestyle, diet, medical history, and biological measurements. Neonatal outcomes, including abnormal birth weight, will be evaluated at birth, and children will be followed until one year of age to assess growth, health events, and developmental outcomes. Biological samples collected at different times during the study will allow the assessment of chemical exposures and epigenetic markers. This study aims to generate original French twin pregnancy data and to improve understanding of environmental determinants of early-life health.

Conditions

  • Pregnancy
  • Twin

Interventions

OTHER

Biological samples from the mother

During pregnancy, the research team collects: \- 15 ml of urine from the expectant mother. Immediately after delivery, the research team collects: * 10 ml of peripheral blood from the mother * One or two 2 cm x 2 cm pieces of placenta, depending on the type of pregnancy * 12 ml of cord blood for each twin * A 5 cm fragment of cord tissue for each twin

OTHER

Biological samples from the twins

The day after delivery, the reserch team collects: \- A meconium sample from each twin At 6 months and 1 year of age, the parents collect: \- A stool sample from each twin

Sponsors & Collaborators

  • Institut National de la Santé Et de la Recherche Médicale, France

    collaborator OTHER_GOV

  • University Hospital, Montpellier

    lead OTHER

Principal Investigators

  • Florent FUCHS, MD, PhD · University Hopistal of Montpellier

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-04-01
Primary Completion
2029-03-01
Completion
2029-03-01

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07408973 on ClinicalTrials.gov