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Correlation Between Tumor-infiltrating Lymphocytes and Response to Systemic Therapy in Breast Cancer

NCT07404462 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 171

Last updated 2026-02-19

No results posted yet for this study

Summary

This study aims to investigate the correlation between immune-related factors in the tumor stroma and pathological complete response (pCR) in patients with early breast cancer treated with neoadjuvant chemotherapy. In addition, the study evaluates the association between immune-related tumor stroma factors and the presence of circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) in peripheral blood. The study includes serial blood sampling before and after treatment and during follow-up to assess the prognostic value of these biomarkers for disease progression and recurrence.

Conditions

Interventions

OTHER

Standard-of-Care Neoadjuvant Chemotherapy

Standard neoadjuvant chemotherapy administered as part of routine clinical care. The regimen is determined by the treating physician and is not assigned by the study protocol.

Sponsors & Collaborators

  • Institute of Oncology Ljubljana

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-03-01
Primary Completion
2022-03-01
Completion
2022-03-01

Countries

  • Slovenia

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07404462 on ClinicalTrials.gov