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Intraoperative Methylene Blue Spray for the Identification and Preservation of Vital Structures in Thyroidectomy

NCT07395388 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 136

Last updated 2026-02-09

No results posted yet for this study

Summary

This randomized controlled trial aims to evaluate the efficacy of intraoperative methylene blue (MB) spray in improving the identification and preservation of the recurrent laryngeal nerve (RLN) and parathyroid glands (PGs) during thyroidectomy. The study compares outcomes between patients receiving topical MB spray and those undergoing conventional visual dissection alone. Primary outcomes include the incidence of RLN injury and postoperative serum calcium levels.

Conditions

  • Benign Multinodular Goiter
  • Thyroidectomy
  • Recurrent Laryngeal Nerve Injury
  • Hypoparathyroidism

Interventions

PROCEDURE

Intraoperative topical methylene blue spray

Intraoperative topical spray of 0.5 mL methylene blue applied to the thyroid lobe and surrounding tissue after mobilization.

PROCEDURE

Conventional Dissection

Conventional visual identification and dissection without dye.

Sponsors & Collaborators

  • Services Hospital, Lahore

    lead OTHER_GOV

Principal Investigators

  • Awais Amjad Malik, MBBS, FCPS · Services Institute of Medical Sciences

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-01-10
Primary Completion
2025-12-31
Completion
2026-01-20

Countries

  • Pakistan

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07395388 on ClinicalTrials.gov