Universal Chimeric Antigen Receptor T-Cell (UCAR T-cell) Therapy Targeting CD19/ BCMA(QT-019C) in Patients With r/ r Neurological Autoimmune Diseases
NCT07392528 · Status: NOT_YET_RECRUITING · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 15
Last updated 2026-02-11
Summary
This is an open label, single-site, dose-escalation study in up to 15 participants with relapsed or refractory Neurological Autoimmune Diseases. This study aims to evaluate the safety and efficacy of the treatment with universal CD19/BCMA CAR T-cells(QT-019C).
Conditions
- Neuromyelitis Optica Spectrum Disorders
- Multiple Sclerosis
- Myasthenia Gravis
Interventions
- DRUG
-
QT-019C
Universal allogeneic anti-CD19/BCMA CAR T-cells
Sponsors & Collaborators
-
Tianjin Huanhu Hospital
lead OTHER
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2026-03-31
- Primary Completion
- 2027-06-30
- Completion
- 2028-12-31
Countries
- China
Study Locations
More Related Trials
-
CAR T-cell Therapy Targeting CD19 and BCMA in Patients With Relapse/Refractory Autoimmune Diseases
NCT06941129 ·Status: RECRUITING ·Phase: PHASE1
-
Autologous CD19/BCMA Dual-Target CAR-T for Relapsed/Refractory Autoimmune Diseases
NCT07361094 ·Status: RECRUITING ·Phase: PHASE1
-
CAR-T Cells Therapy for Patients With Autoimmune Diseases
NCT07052565 ·Status: RECRUITING ·Phase: NA
-
UCAR T-cell Therapy Targeting CD19/ BCMA in Patients With Relapse/ Refractory Autoimmune Diseases
NCT07155369 ·Status: ACTIVE_NOT_RECRUITING ·Phase: NA
-
Clinical Study on Targeted CD19/BCMA CAR-T Therapy for Autoimmune Diseases
NCT06775912 ·Status: RECRUITING ·Phase: EARLY_PHASE1
-
A Study of CD19 UCAR-T Cells in Subjects With Autoimmune Diseases
NCT07212322 ·Status: NOT_YET_RECRUITING ·Phase: NA
-
BCMA-CD19 CAR-T Therapy for Refractory Autoimmune Diseases
NCT06794008 ·Status: RECRUITING ·Phase: PHASE2
-
Clinical Study on Targeted CD19 or CD19-BCMA CAR-T Therapy for Autoimmune Diseases
NCT06548607 ·Status: RECRUITING ·Phase: EARLY_PHASE1
-
A Study of BCMA/CD19 Dual-Target CAR-T Cell Immunotherapy for Relapsed or Refractory Multiple Myeloma
NCT04182581 ·Status: UNKNOWN ·Phase: EARLY_PHASE1
-
CD19/BCMA CAR-T for SLE
NCT07266337 ·Status: NOT_YET_RECRUITING ·Phase: EARLY_PHASE1
-
CAR T-cell Therapy Targeting CD19 and BCMA in Patients With B Cell Mediated Autoimmune Disease
NCT07305116 ·Status: RECRUITING ·Phase: PHASE1
-
UCAR T-cell Therapy Targeting CD19/BCMA in Patients With r/r Autoimmune Hemolytic Anemia
NCT06920446 ·Status: NOT_YET_RECRUITING ·Phase: EARLY_PHASE1
-
Exploratory Study of Anti-BCMA-CD19 CAR-T Cell Therapy in Relapsed or Refractory IgG4-Related Disease
NCT07148791 ·Status: RECRUITING ·Phase: PHASE2
-
The Safety and Efficacy of Anti-CD19 CAR-T Cells in Patients With Relapsed/Refractory Autoimmune Diseases
NCT06420154 ·Status: NOT_YET_RECRUITING ·Phase: EARLY_PHASE1
-
A Study of BCMA/CD19 Dual-Target CAR-T Cell Immunotherapy for Relapsed or Refractory MM
NCT04412889 ·Status: UNKNOWN ·Phase: EARLY_PHASE1
-
UCAR T-cell Therapy Targeting CD19/BCMA in Patients With r/r Systemic Lupus Erythematosus
NCT06920433 ·Status: RECRUITING ·Phase: EARLY_PHASE1
-
UCAR T-cell Therapy Targeting CD19/BCMA in Patients With r/r Myasthenia Gravis
NCT06933563 ·Status: NOT_YET_RECRUITING ·Phase: EARLY_PHASE1
-
An Exploratory Clinical Study of SCAR02 Targeting BCMA and CD19 for the Treatment of Refractory Autoimmune Diseases
NCT06503224 ·Status: RECRUITING ·Phase: NA
-
BCMA-CD19 CCAR T Cell Treatment of Refractory Immune Thrombocytopenia Associated with Autoimmune Diseases
NCT06787989 ·Status: RECRUITING ·Phase: PHASE1
-
Study of T Cells Targeting CD19/BCMA (CART-19/BCMA) for High Risk Multiple Myeloma Followed With Auto-HSCT
NCT03455972 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1/PHASE2
-
Study of Therapeutic Efficacy of Anti-CD19 CAR-T Cells in Refractory Systemic Lupus Erythematosus
NCT06222853 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
Targeting CD19 and CD22 CAR-T Cells Immunotherapy in Patients With Relapsed or Refractory Acute B Lymphocytic Leukemia
NCT04714593 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Fourth-gen CAR T Cells Targeting BCMA/CD19 for Refractory Systemic Lupus Erythematosus (SLE)
NCT06350110 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Safety and Efficacy of CD19 CAR-T Therapy for Recurrent/Refractory Autoimmune Diseases
NCT06983964 ·Status: RECRUITING ·Phase: NA
-
Anti-CD19 Chimeric Antigen Receptor T Cells for Refractory Autoimmune Diseases
NCT07161193 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1/PHASE2