Semaglutide PrIor to CathEeter Ablation in Patients With Atrial Fibrillation
NCT07389941 · Status: NOT_YET_RECRUITING · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 240
Last updated 2026-02-11
Summary
To evaluate whether pre-treatment with semaglutide is superior to standard care in improving freedom from atrial fibrillation (AF) at 12 months following catheter ablation in patients with obesity and symptomatic AF undergoing first-time ablation.
Conditions
- Atrial Fibrillation (AF)
Interventions
- DRUG
-
Semaglutide (SEMA)
Catheter ablation for AF plus semaglutide (up to 2.4 mg weekly)
Sponsors & Collaborators
-
University of Luebeck
lead OTHER
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- SINGLE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2026-10-31
- Primary Completion
- 2029-04-30
- Completion
- 2029-04-30
More Related Trials
-
Impact of Life-Style Modification On Ablation Outcome in Atrial Fibrillation
NCT02219841 ·Status: UNKNOWN
-
Effect of Complex Weight-reducing Interventions on Rhythm Control in Obese Subjects With Atrial Fibrillation
NCT04560387 ·Status: UNKNOWN ·Phase: NA
-
Bariatric Atrial Restoration of Sinus Rhythm
NCT04050969 ·Status: TERMINATED ·Phase: NA
-
TIRzepatide for the Treatment of Obesity in Patients With Atrial Fibrillation
NCT06802081 ·Status: RECRUITING ·Phase: PHASE2
-
Medtronic Terminate AF Study
NCT03546374 ·Status: RECRUITING ·Phase: NA
-
Ablating Atrial Tachycardias Occuring During Ablation of Complex Fractionated Electrograms in Persistent AF
NCT01229033 ·Status: COMPLETED ·Phase: NA
-
Interventional Strategies in Treatment of Atrial Fibrillation: Percutaneous Closure of the Left Atrial Appendage Versus Catheter Ablation
NCT01363895 ·Status: COMPLETED ·Phase: NA
-
STOP AF First: Cryoballoon Catheter Ablation in an Antiarrhythmic Drug Naive Paroxysmal Atrial Fibrillation
NCT03118518 ·Status: COMPLETED ·Phase: NA
-
Assessment of the Sphere-9™ Catheter and Affera Mapping and Ablation System for Treatment of Atrial and Ventricular Arrhythmias
NCT04211441 ·Status: COMPLETED ·Phase: NA
-
Atrial Fibrillation and Diabetes Mellitus
NCT05873920 ·Status: UNKNOWN
-
Ablation vs Amiodarone for Treatment of AFib in Patients With CHF and an ICD
NCT00729911 ·Status: COMPLETED ·Phase: PHASE4
-
Catheter Ablation for Atrial Fibrillation in Preserved Ejection Fraction
NCT04317911 ·Status: COMPLETED
-
Strict Weight Management Based on GLP-1 RA for Ablation Outcomes in Overweight or Obese Patients with T2DM and AF
NCT06660134 ·Status: COMPLETED ·Phase: NA
-
Assessing the Neurological Outcomes After Atrial Fibrillation Ablation for Rhythm Control
NCT06783868 ·Status: NOT_YET_RECRUITING
-
Catheter Cryoablation Versus Antiarrhythmic Drug as First-Line Therapy of Paroxysmal Atrial Fibrillation
NCT01803438 ·Status: COMPLETED ·Phase: PHASE4
-
Catheter Ablation Versus Medical Treatment of AF in Heart Failure
NCT01411371 ·Status: UNKNOWN ·Phase: NA
-
Prevalence and Predictors of Esophageal Thermal Lesions in High-power-Short-duration Ablation of Atrial Fibrillation
NCT05709756 ·Status: COMPLETED
-
Impact of Catheter Ablation on ABC Risk Scores
NCT05635864 ·Status: COMPLETED
-
Totally Endoscopic Ablation of Atrial Fibrillation
NCT00940056 ·Status: COMPLETED ·Phase: NA
-
Efficacy of Aldosterone Antagonist Therapy for Prevention of New Atrial Fibrillation
NCT03929718 ·Status: ACTIVE_NOT_RECRUITING ·Phase: EARLY_PHASE1
-
Shape vs Substrate in AF
NCT05993104 ·Status: WITHDRAWN
-
Ablation of Perimitral Flutter Following Catheter Ablation of Atrial Fibrillation: Impact on Outcomes
NCT01173796 ·Status: COMPLETED ·Phase: PHASE3
-
An Initial Assessment of the Sphere-9™ Catheter and Affera Mapping and Ablation System
NCT04210622 ·Status: COMPLETED
-
Treatment of Persistent Atrial Fibrillation With Sphere-9 Catheter and Affera Mapping and Ablation System
NCT05120193 ·Status: COMPLETED ·Phase: NA
-
Reducing Recurrence of Symptomatic Atrial Fibrillation After Catheter Ablation by App-based Mental Training
NCT04067427 ·Status: COMPLETED ·Phase: NA