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[Effects of Selected Statins on Cardiovascular Parameters in Healthy Volunteers]

NCT07389304 · Status: NOT_YET_RECRUITING · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 100

Last updated 2026-02-05

No results posted yet for this study

Summary

This study is a Phase I randomized clinical trial aiming to investigate the short-term effects of three commonly prescribed statins i.e (Atorvastatin, Rosuvastatin, and Simvastatin) at different dose levels i.e lo,median and high doses on cardiovascular parameters i.e Blood pressure and ECG morphology in healthy volunteers. The study will assess changes in blood pressure and ECG morphology following two days of statin administration under controlled conditions.

Conditions

  • Lipid Profile,Blood Pressure

Interventions

DRUG

Rosuvastatin (5mg, 20mg, 40mg)

The Rosuvastatin (5mg, 20mg, 40mg) group participants will be given the drug orally OD for two days

DRUG

Atorvastatin (10mg, 20mg, 40mg)

The Atorvastatin (10mg, 20mg, 40mg) group participants will be given the drug orally OD for two days

DRUG

Simvastatin (10mg, 20mg, 40m

The Simvastatin (10mg, 20mg, 40mg) group participants will be given the drug orally OD for two days

Sponsors & Collaborators

  • Khyber Medical University Peshawar

    collaborator OTHER

  • Shaheed Benazir Bhutto University Sheringal Dir Upper

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
25 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-03-01
Primary Completion
2026-12-30
Completion
2027-02-20

Countries

  • Pakistan

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07389304 on ClinicalTrials.gov