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Study of Imaging and Molecular Biomarkers in Uncomplicated Rhegmatogenous Retinal Detachment

NCT07386678 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2026-05-06

No results posted yet for this study

Summary

Disease or general study area: Uncomplicated rhegmatogenous retinal detachment (RRD) and risk of proliferative vittroretinopathy (PVR)

Purpose and nature of the study:

1. Characterise the cytokine profile of vitreous fluid in uncomplicated RRD.
2. Develop a risk model to predict development of PVR after retinal detachment surgery using imaging and molecular biomarkers.
3. To develop deep learning/artificial intelligence (AI) models for PVR detection in retinal detachment.

Inclusion criteria:

50 adult ( ≥18 years) patients with uncomplicated rhegmatogenous retinal detachments without PVR.

What participating will involve:

Pre- and post-operative assessments and intervention will follow standard of care for patients with rhegmatogenous retinal detachments.

Additional intervention will include non-invasive imaging of anterior chamber flare, vitreous, wide-field retina, macula optical coherence tomography (OCT) and macula OCT-angiography (OCT-A) as well as, seeking participant's consent on collecting their vitreous fluid at time of their surgery for cytokine analysis.

Conditions

  • Retinal Detachment Rhegmatogenous
  • Proliferative Vitreoretinopathy
  • Proliferative Vitreoretinopathy in Rhegmatogenous Retinal Detachment

Sponsors & Collaborators

  • University College, London

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-04-27
Primary Completion
2027-01-27
Completion
2027-01-27

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07386678 on ClinicalTrials.gov