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Comparison of Nebulized Ketamine With Nebulized Magnesium Sulfate for the Prevention of Postoperative Sore Throat

NCT07381036 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 150

Last updated 2026-02-03

No results posted yet for this study

Summary

The aim of this study is to compare the efficacy of nebulized ketamine versus nebulized magnesium sulfate in reducing the incidence and severity of POST.

* Primary outcome

• To compare the incidence of POST method.
* Secondary outcomes

* Onset, Severity, and duration of POST at 0, 2, 4, 6, 12, 24 hours postoperative.
* The hemodynamics recording (HR, BP, MBP, pre and post nebulization)
* Adverse Effects (e.g., sedation, cough, nausea, vomiting, ….)

Conditions

  • Postoperative Sore Throat

Interventions

DRUG

Ketamine nebulizer

50 patients will receive preoperative nebulization with 50 mg ketamine in 5 ml normal saline.

DRUG

Mg sulfate nebulizer

50 patients will receive preoperative nebulization with 250 mg magnesium sulfate in 5 ml normal saline.

DRUG

Placebo

50 patients will receive preoperative nebulization with 5 ml normal saline.

Sponsors & Collaborators

  • Sohag University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-02-01
Primary Completion
2026-07-01
Completion
2026-09-01

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Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07381036 on ClinicalTrials.gov