Telmisartan for Prevention of Doxorubicin-Induced Cardiotoxicity in Breast Cancer Patients
NCT07370506 · Status: NOT_YET_RECRUITING · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 36
Last updated 2026-01-29
Summary
This study aims to evaluate the efficacy and safety of telmisartan as a cardioprotective agent in patients receiving doxorubicin-based chemotherapy, with the goal of reducing treatment-associated cardiotoxicity, optimizing therapeutic outcomes, and facilitating the safer administration of anthracycline regimens.
Conditions
- Breast Cancer
- Doxorubicin Induced Cardiomyopathy
Interventions
- DRUG
-
Telmisartan
Telmisartan administered orally once daily as cardioprotective therapy during doxorubicin-based chemotherapy.
- DRUG
-
Doxorubicin (DOX)
Standard doxorubicin-based chemotherapy according to institutional protocol.
Sponsors & Collaborators
-
Tanta University
lead OTHER
Study Design
- Allocation
- RANDOMIZED
- Purpose
- PREVENTION
- Masking
- NONE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Max Age
- 65 Years
- Sex
- FEMALE
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2026-02-28
- Primary Completion
- 2027-01-31
- Completion
- 2027-02-28
Countries
- Egypt
Study Locations
More Related Trials
-
Risk-Guided Cardioprotection With Carvedilol in Breast Cancer Patients Treated With Doxorubicin and/or Trastuzumab
NCT04023110 ·Status: COMPLETED ·Phase: PHASE1
-
CardioPROTECTion with Dapagliflozin in Breast Cancer Patients Treated with AnthrAcycline - PROTECTAA TRIAL
NCT06304857 ·Status: RECRUITING ·Phase: PHASE3
-
Effect of Anthracyclines and Cyclophosphamide on Cardiovascular Responses
NCT04568161 ·Status: COMPLETED ·Phase: NA
-
Cardiotoxicity in Breast Cancer Patients
NCT06491680 ·Status: RECRUITING ·Phase: PHASE4
-
Prevention of Heart Failure Induced by Doxorubicin With Early Administration of Dexrazoxane
NCT03930680 ·Status: COMPLETED ·Phase: PHASE1
-
Enalapril Maleate and Doxorubicin Hydrochloride in Treating Women With Breast Cancer
NCT00895414 ·Status: COMPLETED ·Phase: NA
-
Side Effects Involving the Heart in Women With Breast Cancer Receiving Doxorubicin and Trastuzumab
NCT00875238 ·Status: COMPLETED
-
Pilot Study to Evaluate the Prevention and Safety of Doxorubicin-induced Cardiomyopathy Using Extracorporeal Shock Waves
NCT05584163 ·Status: UNKNOWN ·Phase: NA
-
Effect of Montelukast on Doxorubicin Induced Cardiotoxicity in Breast Cancer
NCT05959889 ·Status: COMPLETED ·Phase: NA
-
Mechanisms, Predictors, and Social Determinants of Cardiotoxicity in Breast Cancer
NCT05078190 ·Status: ACTIVE_NOT_RECRUITING
-
Doxorubicin and Cyclophosphamide in Treating Older Women With Stage I, Stage II, or Stage III Breast Cancer That Has Been Removed By Surgery
NCT00424203 ·Status: COMPLETED ·Phase: PHASE2
-
Genomic & Proteomic Analysis of Docetaxel & Capecitabine as Primary Chemo for Stage II-III Breast Cancer
NCT00198237 ·Status: COMPLETED ·Phase: PHASE2
-
Phase II Study of Neoadjuvant Chemotherapy With Doxorubicin Followed by Docetaxel-Cisplatin in Locally Advanced Breast Cancer
NCT00538525 ·Status: COMPLETED ·Phase: NA
-
Reporting, Evaluating, Preventing and Treating the Cardiotoxicity Induced by Anticancer Drugs During a Specific Cardio-oncology Consult and Follow up in Routine Care
NCT03882580 ·Status: UNKNOWN
-
Prevention of Cardiac Dysfunction During Breast Cancer Therapy
NCT03760588 ·Status: COMPLETED ·Phase: PHASE2
-
Effect of DAPAglifozin on MYOcardial Remodeling of Breast CANCER Patients Treated with Anthracycline Based Chemotherapy
NCT06711185 ·Status: RECRUITING ·Phase: PHASE3
-
Docetaxel in Breast Cancer
NCT00312208 ·Status: COMPLETED ·Phase: PHASE3
-
Phase II Trial to Compare the Safety of Two Chemotherapy Plus Trastuzumab Regimens as Adjuvant Therapy for HER2-positive Breast Cancer (Study P05048)
NCT00550771 ·Status: COMPLETED ·Phase: PHASE2
-
Effect of Concomitant Radiotherapy and Trastuzumab on Cardiotoxicity of Patients Treated for Early Breast Cancer
NCT01572883 ·Status: COMPLETED
-
Early Detection and Prediction of Chemotherapy Induced Cardiac Toxicity in Breast Cancer Patients
NCT00806507 ·Status: COMPLETED
-
Trastuzumab Deruxtecan in Advanced Breast Cancer
NCT07180264 ·Status: RECRUITING
-
Risk and Clinical Benefit of Chemotherapy and Intensive Endocrine Therapy for Luminal B1 Early-stage Breast Cancer
NCT03373708 ·Status: UNKNOWN ·Phase: PHASE2/PHASE3
-
A Safety and Efficacy Study of Bavituximab Plus Docetaxel in Patients With Advanced Breast Cancer
NCT00669591 ·Status: COMPLETED ·Phase: PHASE2
-
A Pharmacogenomics Study for Breast Cancer Patients Undergoing Adjuvant Chemotherapy With Doxorubicin (A)/Cyclophosphamide ©) and/or Weekly Paclitaxel
NCT00131963 ·Status: COMPLETED
-
Chemotherapy in Treating Women With Breast Cancer That Can Be Surgically Removed
NCT00002707 ·Status: COMPLETED ·Phase: PHASE3