CDK4/6 Inhibitors Combined With Endocrine Therapy for Neoadjuvant Treatment
NCT07366112 · Status: NOT_YET_RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 158
Last updated 2026-01-26
Summary
Exploring the dynamics of ctDNA following neoadjuvant therapy with CDK4/6 inhibitors combined with endocrine treatment, and its potential to guide de-escalation of adjuvant chemotherapy
Conditions
- Hormone Receptor-Positive Breast Cancer
- High-risk Breast Cancer
- Early-Stage Breast Cancer
- HER2-negative Breast Cancer
- ctDNA Monitoring
Interventions
- DRUG
-
CDK4/6 inhibitor with endocrine therapy
CDK4/6 inhibitor with endocrine therapy for neoadjuvent therapy
Sponsors & Collaborators
-
Peking University People's Hospital
lead OTHER
Principal Investigators
-
shu wang, doctor · Peking University People's Hospital
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Max Age
- 75 Years
- Sex
- FEMALE
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2026-02-01
- Primary Completion
- 2028-01-01
- Completion
- 2029-12-31
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