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Localized Injection of Lidocaine Via the Middle Meningeal Artery for Intractable Headache Treatment

NCT07361549 · Status: NOT_YET_RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 80

Last updated 2026-01-23

No results posted yet for this study

Summary

The goal of this clinical trial is to test whether injecting lidocaine into two blood vessels of the brain can help treat chronic headaches (migraines)

Conditions

Interventions

DRUG

Lidocaine (drug)

Intra-arterial lidocaine infusion into bilateral middle meningeal arteries

DRUG

Saline

Intra-arterial saline infusion into bilateral middle meningeal arteries

Sponsors & Collaborators

  • Daniel A Tonetti, MD

    lead OTHER

Principal Investigators

  • Manisha Koneru, MD · The Cooper Health System

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-03-31
Primary Completion
2030-12-31
Completion
2031-07-31
FDA Drug
Yes

Countries

  • United States

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07361549 on ClinicalTrials.gov