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Resistance Training Added to Aerobic Interval Training to Improve Aerobic Capacity and Muscle Mass in Women With Coronary Artery Disease

NCT07354399 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 50

Last updated 2026-01-21

No results posted yet for this study

Summary

The goal of this clinical trial is to find out whether partly replacing aerobic interval training (AIT) with resistance training (RT) leads to greater improvements in physical fitness and muscle mass in women with coronary artery disease (CAD) during cardiac rehabilitation.

The main questions this study aims to answer are:

* Does combining RT (squats and pulling exercises with weights) with a reduced amount of AIT (cycling) improve aerobic fitness in the same way as AIT alone?
* Does the combined training lead to greater improvements in muscle mass compared with AIT alone?
* Does slow-speed RT (slower lowering phase) result in lower heart rate and blood pressure during exercise compared with normal-speed RT?

Researchers will compare three exercise programs:

* AIT only (control group),
* AIT combined with normal-speed RT (1-second lifting, 2-second lowering),
* AIT combined with slow-speed RT (1-second lifting, 5-second lowering).

Participants will take part in a 12-week cardiac rehabilitation program and will train three times per week.

At the start and end of the program, participants will complete a cycling fitness test, body composition assessment, blood sampling, two strength tests, and quality-of-life questionnaire.

Conditions

  • Coronary Artery Disease With Myocardial Infarction

Interventions

OTHER

Aerobic Interval Training

Interval cycling, performed at 70-80% of the heart rate reserve (HRR) as determined during the cardiopulmonary exercise test. The training is structured as alternating high- and low-intensity intervals.

OTHER

Traditional Resistance Training

Resistance training with traditional tempo (1-second ascent, 2-second descent) - squat exercise and horizontal pull.

OTHER

Prolonged Eccentric Phase Resistance Training

Resistance training with prolonged eccentric phase tempo (1-second ascent, 5-second descent) - squat exercise and horizontal pull.

Sponsors & Collaborators

  • University Medical Centre Ljubljana

    lead OTHER

Principal Investigators

  • Borut Jug, MD, Ph.D. · University Medical Centre Ljubljana, Slovenia

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-09-26
Primary Completion
2026-10-31
Completion
2026-11-30

Countries

  • Slovenia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07354399 on ClinicalTrials.gov