MedTrace Logo

PRP Plus Fractional CO₂ Laser for Acne Scars

NCT07352215 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 70

Last updated 2026-01-20

No results posted yet for this study

Summary

This randomized controlled trial aims to evaluate whether adding platelet-rich plasma (PRP) to fractional CO₂ laser resurfacing improves the treatment of moderate-to-severe acne scars compared with laser alone. Seventy adults aged 18-40 years will be recruited from the Dermatology Department of Gujranwala Medical College Teaching Hospital. Participants will be randomly assigned to receive either fractional CO₂ laser combined with topical PRP or fractional CO₂ laser alone, with three treatment sessions delivered four weeks apart.

The primary outcome is the change in acne scar severity measured using the Goodman and Baron Quantitative Acne Scar Scale. Secondary outcomes include redness, edema, pain scores, and patient satisfaction assessed using Likert and numeric rating scales. The study is single-blinded, with patients unaware of treatment allocation. PRP will be prepared using a standardized double-spin centrifugation process. Data will be analyzed using appropriate statistical tests with a significance level of p \< 0.05. The study aims to determine whether PRP enhances laser efficacy, reduces side effects, and improves patient-reported outcomes.

Conditions

  • Post-Acne Atrophic Scars
  • Carbon Dioxide Lasers
  • Platelet-Rich Plasma

Interventions

PROCEDURE

Fractional CO₂ Laser + Platelet-Rich Plasma (PRP)

Fractional CO₂ Laser + Platelet-Rich Plasma (PRP) Participants receive fractional CO₂ laser treatment followed by topical application of autologous platelet-rich plasma. Three treatment sessions are performed at four-week intervals. PRP is prepared using a standardized double-spin centrifugation method from 10 mL of the participant's blood. After laser resurfacing, the PRP is applied immediately to the treated area to enhance healing and collagen remodeling.

PROCEDURE

Fractional CO₂ Laser Only

Fractional CO₂ Laser Only Participants receive fractional CO₂ laser treatment alone, with the same laser settings and treatment schedule as the intervention group. Three sessions are performed at four-week intervals. To maintain participant blinding, a placebo-filled syringe covered with opaque tape is applied to the skin without delivering PRP.

Sponsors & Collaborators

  • Saglik Bilimleri Universitesi

    collaborator OTHER

  • Gujranwala medical college District Headquarters Hospital, Gujranwala

    lead OTHER

Principal Investigators

  • YASAAN SAAQIB · Gujranwala Medial College Gujranwala

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-10-31
Primary Completion
2026-01-12
Completion
2026-04-30

Countries

  • Pakistan

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07352215 on ClinicalTrials.gov