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Electrophysiology-based DBS Programming for PD

NCT07348705 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2026-03-30

No results posted yet for this study

Summary

Deep brain stimulation (DBS) effectively alleviates motor symptoms in Parkinson's disease (PD). However, current programming is manual and time-consuming. This study will evaluate physiology-based programming using local field potentials (LFPs) to identify optimal stimulation parameters. Specifically, DBS contact selection based on beta power and a broad-band approach will be compared with conventional clinician-based programming.

Conditions

  • Parkinson's Disease (PD)

Interventions

DEVICE

Clinician-based DBS programming

Contacts, amplitude, pulse width, and frequency are chosen by the treating physician during a conventional monopolar review.

DEVICE

Maximum Beta power-based DBS programming

The contact that shows the strongest beta activity (13-30 Hz) in the local field potentials is selected for stimulation.

DEVICE

Broad-band electrophysiology-based DBS programming

A multi-frequency algorithm that integrates beta, theta/alpha, finely tuned gamma, and other relevant bands is used to identify the optimal contact.

Sponsors & Collaborators

  • University of Florida

    lead OTHER

Principal Investigators

  • Joshua Wong, MD · University of Florida

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
21 Years
Max Age
89 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-01-15
Primary Completion
2027-01-15
Completion
2031-01-15
FDA Device
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07348705 on ClinicalTrials.gov