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Chair Exercise and Intergenerational Activities in Older Adults With Physio-Cognitive Decline Syndrome

NCT07335978 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 100

Last updated 2026-05-04

No results posted yet for this study

Summary

The goal of this clinical trial is to investigate the effects of chair exercise followed by intergenerational activity in frailty syndrome and changes in serum mBDN levels among older adults with Physio-Cognitive Decline Syndrome (PCDS), as a novel approach integrating physical and social intervention with biomolecular assessments

In older adults with PCDS

1. Does A 16-week program of chair exercise followed by intergenerational activity improve handgrip strength (HGS), gait speed, MoCA-Ina scores, and health-related quality of life?
2. Does a 16-week program of chair exercise followed by an intergenerational activity increase serum mBDNF level?
3. Are serum mBDNF levels associated with MoCA-Ina scores, gait speed, and handgrip strength?

Intervention Group

Participants will undergo a 12-week structured chair exercise program, conducted with a trained exercise instructor and supervised by a physician for vital sign monitoring during each session. The frequency of sessions will increase progressively:

* Weeks 1-2: once weekly
* Weeks 3-6: twice weekly
* Week 7-12: three times weekly

Additional activities include (intervention and control group):

* Weeks 1 and 11: teleconference session on nutrition and physical exercise supported by electronic flyers (e-flyers).
* Weeks 3, 5, 7, 11, and 13: distribution of e-flyers on elderly nutrition and the muscle-brain axis.

Additional Activity (intervention group)

\- Weeks 13-16: intergenerational activities at an orphanage with children aged \>5 years

Assessments (intervention and control group):

* Week 1: serum mBDNF and HbA1c measurement
* Week 12 and 16: physical assessments (body weight, height, handgrip strength, gait speed, MoCA-Ina, and IADL) and serum mBDNF measurement.

Control Group:

The participant will receive general health education on performing physical exercise 1-3 times per week throughout week 1-16

Conditions

  • Cognitive Frailty

Interventions

BEHAVIORAL

Intervention 1

Nutritional education + 12 weeks structured chair-based exercise (PEROSI protocol, progressive frequency from 1 to 3 sessions/week, 60 minutes/session, supervised online) followed sequentially by 4 weeks SHP-based intergenerational activities (8 sessions, 2x/week, 45 minutes/session, paired 1:1 elderly-child using AMIR educational materials at selected orphanages).

Sponsors & Collaborators

  • Atma Jaya Catholic University of Indonesia

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
60 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-09-24
Primary Completion
2026-03-16
Completion
2026-03-16

Countries

  • Indonesia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07335978 on ClinicalTrials.gov