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Exercise Balance Program for Fall Prevention in Multiple Sclerosis

NCT07331350 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2026-05-28

No results posted yet for this study

Summary

Falls and balance impairments are common in individuals with multiple sclerosis (MS) and may negatively affect mobility, independence, confidence in daily activities, and quality of life, while increasing the risk of injury. This randomized controlled trial investigated the effects of a 6-week combined Otago-based and game-inspired balance-training program on static balance, functional mobility, fear of falling, and perceived walking ability in individuals with MS. Thirty participants with MS were randomly allocated to either an intervention group or an active control group. Both groups received fall-prevention counselling and performed home-based Otago-related exercises three times per week. The intervention group additionally received one supervised balance-training session per week using colored-circle and Twister-inspired task-oriented exercises. Outcomes were assessed at baseline and immediately after the intervention period using the FICSIT-4 for static balance, the Timed Up and Go test for functional mobility, the Falls Efficacy Scale-International (FES-I) for fear of falling, and the 12-item Multiple Sclerosis Walking Scale (MSWS-12) for perceived walking limitations.

Conditions

Interventions

OTHER

Combined Otago-Based and Game-Inspired Balance Training

This intervention combined home-based Otago-related exercises with supervised task-oriented balance training. The home-based component included selected balance and lower-limb strengthening exercises performed three times per week. The supervised component was delivered once weekly and included exercises with colored floor markers, postural tasks linked to color cues, and Twister-inspired stepping activities. These tasks were used to challenge postural control, coordination, visuomotor responses, and movement adaptability.

OTHER

Otago Exercise Program only

This intervention consisted of selected Otago-related balance and lower-limb strengthening exercises performed at home three times per week for 6 weeks. Participants also received fall-prevention counselling and instructional material for home practice. No supervised colored-marker or Twister-inspired balance tasks were included.

Sponsors & Collaborators

  • International Hellenic University

    lead OTHER

Principal Investigators

  • Dimitrios Lytras, PhD · International Hellenic University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-02-01
Primary Completion
2026-05-10
Completion
2026-05-10

Countries

  • Greece

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07331350 on ClinicalTrials.gov