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Neurobiological and Genomic Predictors of Relapse in Depression

NCT07328373 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 204

Last updated 2026-01-09

No results posted yet for this study

Summary

The goal of this observational study is to test whether the discontinuation of antidepressant medications for patients with depression can be decided after the normalization of biological parameters. The main questions it aims are:

1. When patients with depression treated with antidepressants, does their brain activity also become normal? If so,
2. Then, can we stop the antidepressant treatment and expect minimum repeat of depression?

The participants who receive a specific antidepressant treatment will be asked to:

* Undergo quantitative electroencephalography (qEEG),
* Record Event-related potential (ERP),
* Record Sleep EEG
* Answer Hamilton Depression Rating Scale question their psychiatrists asked
* Give blood sample for genetic analysis
* Repeat the above mentioned procedures for at least 3 times during their treatment period.

Researchers will compare the results of patients with the results of healthy controls.

Conditions

  • Healthy
  • Major Depressive Disorder (MDD)

Interventions

DRUG

Antidepressant Medications

Second generation antidepressants under "selective serotonin reuptake inhibitor" group

Sponsors & Collaborators

  • Mehmet Kemal Arikan

    lead OTHER

Principal Investigators

  • Mehmet Kemal Arıkan, Prof. · Kemal Arikan Psychiatry Clinic

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-01-01
Primary Completion
2026-10-01
Completion
2027-02-01

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07328373 on ClinicalTrials.gov