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Tonic Pain and Transauricular Vagal Nerve Stimulation

NCT07325058 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 36

Last updated 2026-01-08

No results posted yet for this study

Summary

This study aims to explore the effect of burst-taVNS (electric stimulation of the concha cymba) on tonic (capsaicin-induced skin pain) and acute (pressure pain sensitivity) experimental pain and cardioception. Primary outcomes include pain intensity. Secondary outcomes include sensory thresholds, resting heart rate (EKG), pupillary measurements and conditioned pain modulation.

Conditions

  • Experimental Pain in Healthy Human Subjects

Interventions

DEVICE

taVNS

Two-headed ball-point electrode which is placed in the concha cymba.

DEVICE

Earlobe Stimulation

Circular urface adhering electrodes will be attached to either facet of the earlobe.

DEVICE

Sham (No Treatment)

Circular surface adhesive electrodes will be placed on either facet of the earlobe. No current will pass through the electrodes.

Sponsors & Collaborators

  • Aalborg University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Model
CROSSOVER

Eligibility

Min Age
16 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-12-18
Primary Completion
2026-03-31
Completion
2026-04-30

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07325058 on ClinicalTrials.gov