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Role of Myeloid-derived Suppressor Cells In Primary Myelofibrosis

NCT07319026 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 70

Last updated 2026-01-06

No results posted yet for this study

Summary

The goals of this observational study are to investigate the role of myeloid-derived suppressor cells (MDSCs) in fueling chronic inflammation that is a relevant pathogenetic mechanism in patients with primary myelofibrosis (PMF), to study modifications in MDSC phenotype and function after treatment with JAK-inhibitors (JAK-i) and to test their participation in the neoangiogenic process. The main questions it aims to answer are:

* Do the frequency and function of MDSCs contribute to induce or sustain the inflammatory status that characterizes PMF?
* Does the number of circulating MDSCs in PMF patients correlate with clinical/biological parameters?
* Are MDSCs involved in the neoangiogenic processes that characterizes PMF?

Conditions

  • Primary Myelofibrosis (PMF)
  • Healthy Subjects

Sponsors & Collaborators

  • Fondazione IRCCS Policlinico San Matteo di Pavia

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
99 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-11-14
Primary Completion
2025-03-31
Completion
2025-03-31

Countries

  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07319026 on ClinicalTrials.gov