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External Validation of the CLOVER Score for Detecting Occult Cancer in Venous Thromboembolism Patients

NCT07310693 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 500

Last updated 2025-12-30

No results posted yet for this study

Summary

This study aims to externally validate the CLOVER score, a machine learning-based predictive model designed to identify patients with venous thromboembolism (VTE) who are at increased risk of having an occult cancer. The study includes a retrospective cohort of patients with acute symptomatic VTE diagnosed between 2000 and 2022, and a prospective cohort of consecutively recruited patients from December 2025 to December 2027. The CLOVER model will be applied to all participants, and its ability to discriminate between patients with and without occult cancer will be evaluated. The study also assesses clinicians' satisfaction with the web-based tool (CLOVER-Web) developed to facilitate the use of the score in clinical practice.

Conditions

  • Venous Thromboembolism (VTE)
  • Occult Cancer

Sponsors & Collaborators

  • Fundación para la Investigación e Innovación Biomédica del Hospital Universitario Infanta Leonor

    collaborator UNKNOWN

  • Infanta Leonor University Hospital

    lead OTHER

Principal Investigators

  • Anabel Franco-Moreno, MD, PhD · Hospital Universitario Infanta Leonor

  • Franco-Moreno, MD, PhD · Hospital Universitario Infanta Leonor

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-12-01
Primary Completion
2028-12-31
Completion
2028-12-31

Countries

  • Spain

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07310693 on ClinicalTrials.gov