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A Phase 1b Study of Lonitoclax + Azacitidine in Acute Myeloid Leukemia Patients

NCT07303660 · Status: NOT_YET_RECRUITING · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 66

Last updated 2025-12-26

No results posted yet for this study

Summary

This is a clinical study aiming to evaluate the safety, pharmacokinetics, pharmacodynamics, and preliminary efficacy of ZE50-0134 in relapsed and refractory Acute Myeloid Leukemia patients.

Conditions

Interventions

DRUG

ZE50-0134

Oral capsules BID

DRUG

Azacitidine Days 1-7

75 mg/m2 daily, days 1-7

DRUG

ZE 50-0134

Oral capsules QD

Sponsors & Collaborators

  • Lomond Therapeutics Holdings, Inc.

    lead INDUSTRY

Study Design

Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
SEQUENTIAL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-01-10
Primary Completion
2026-09-30
Completion
2027-11-30
FDA Drug
Yes

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07303660 on ClinicalTrials.gov