The Effectiveness of Pain Neuroscience Education for Patients With Carpal Tunnel Syndrome

Summary

The goal of this clinical trial is to investigate the effects of Pain Neuroscience Education applied in the treatment of mild and moderate carpal tunnel syndrome (CTS).

The main question it aims to answer is: Does PNE have a therapeutic effect on carpal tunnel syndrome in clinical and ultrasonographic terms? Researchers will compare whether PNE creates a synergistic effect alongside home based exercise programs and splint application in mild to moderate CTS, and will objectively demonstrate potential benefits such as relief from pain and numbness.

Conditions

• Carpal Tunnel Syndrome (CTS)

Interventions

OTHER

Exercise

Stretching the transverse carpal ligament helps correct imbalance and provides more space for the median nerve, supporting nerve mobility. Stretching also balances flexor and extensor muscles, reduces tension, and supports overall hand health. Nerve gliding exercises, similar to stretching, aim to restore nerve mobility and reduce symptoms.

BEHAVIORAL

Pain neuroscience education

PNE is an educational intervention aiming to alter a patient's beliefs and cognitions regarding their pain experience. The main contents addressed in the educational session were: neurophysiological aspects of pain, biopsychosocial aspects of pain, concept of peripheral and central sensitization, using audio-visual support, examples and metaphors for a better understanding by the patient, as reported in previous studies.

Sponsors & Collaborators

• Karaman Training and Research Hospital

  collaborator OTHER

• Karamanoğlu Mehmetbey University

  lead OTHER

Principal Investigators

• Mahmut Talha Susam, MD · Karamanoglu Mehmetbey University Physical Medicine and Rehabilitation

• Mahmut Talha Susam, MD · Karamanoglu Mehmetbey University Physical Medicine and Rehabilitation

• Aynur Başaran, Prof.MD · Karamanoglu Mehmetbey University Physical Medicine and Rehabilitation

• Süleyman Gül, PhD · Karamanoglu Mehmetbey University Physical Medicine and Rehabilitation

• Elif Dilara Durmaz, Pt · Karaman Training and Research Hospital

Study Design

Allocation

RANDOMIZED

Purpose

OTHER

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2025-12-29

Primary Completion

2026-06-15

Completion

2026-08-17

Countries

• Turkey (Türkiye)

Study Locations