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The Effect of Losartan on Cephalexin

NCT07300670 · Status: RECRUITING · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 12

Last updated 2026-03-25

No results posted yet for this study

Summary

The goal of this clinical trial is to investigate the effects of the blood pressure-lowering drug losartan on the blood levels and urinary excretion of the antibiotic cephalexin during simultaneous and staggered ingestion in healthy volunteers. The main questions it aims to answer are:

1. Does losartan affect cephalexin levels and excretion when ingested at the same time?
2. Does a three-hour interval between ingestion of losartan and cephalexin eliminate a possible effect?

Researchers will compare the effects of losartan ingested at the same time, losartan ingested three hours prior, and no losartan ingested on oral cephalexin in each participant to see whether an interaction exists and could be avoided.

Participants will visit the research laboratory on three days during which they will ingest single doses of losartan at the same time with, three hours prior to, and not at all prior to ingesting single doses of cephalexin.

Conditions

  • Possible Interaction Between Losartan and Cephalexin
  • Healthy

Interventions

DRUG

losartan

100 mg tablet orally, single dose

DRUG

cephalexin

500 mg tablet orally, single dose

Sponsors & Collaborators

  • Turku University Hospital

    collaborator OTHER_GOV

  • University of Turku

    collaborator OTHER

  • University of Helsinki

    collaborator OTHER

  • Helsinki University Central Hospital

    collaborator OTHER

  • Aleksi Tornio

    lead OTHER_GOV

Principal Investigators

  • Aleksi Tornio, M.D., Ph.D. · Unit of Clinical Pharmacology, Turku University Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-03-04
Primary Completion
2026-05-08
Completion
2026-05-08

Countries

  • Finland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07300670 on ClinicalTrials.gov