Clinical Trial of VBC103 in Patients With Advanced Malignant Solid Tumors
NCT07299747 · Status: RECRUITING · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 255
Last updated 2026-04-22
Summary
This study is a multicenter, open-label, multi-dose, first-in-human (FIH) Phase I/IIa study to determine the safety and tolerability of VBC103, as well as the maximum tolerated dose (MTD) and/or recommended Phase II dose (RP2D), PK and further evaluate its efficacy.
Conditions
- Participants With Advanced Solid Tumor Malignancies
Interventions
- DRUG
-
VBC103
VBC103
Sponsors & Collaborators
-
VelaVigo Bio Inc
lead INDUSTRY
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2025-12-04
- Primary Completion
- 2027-12-01
- Completion
- 2028-12-01
Countries
- China
Study Locations
More Related Trials
-
This Study Aims to Find and Test a Safe Dose of BI 905677 in Patients With Different Types of Cancer (Solid Tumours)
NCT03604445 ·Status: TERMINATED ·Phase: PHASE1
-
A Dose-escalation Study in Subjects With Advanced Malignancies
NCT01195311 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of XmAb®20717 in Subjects With Selected Advanced Solid Tumors
NCT03517488 ·Status: COMPLETED ·Phase: PHASE1
-
A Phase I/II Clinical Study of SHR-1681 for Injection in Patients With Advanced Solid Tumors
NCT06737731 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
A Study of MHB009C in Patients With Advanced Solid Tumors
NCT07326488 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Phase I Study of BC008-1A Injection in Patients With Advanced Solid Tumors
NCT06773507 ·Status: RECRUITING ·Phase: PHASE1
-
A First-in-human, Dose Escalation and Indication Expansion Study of BNT3212 as Monotherapy or in Combination With BNT327 in Adults With Advanced Solid Tumors
NCT07147348 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
A Phase I Study of Bi-Weekly rBBX-01 in Patients With Solid Tumors
NCT00869388 ·Status: COMPLETED ·Phase: PHASE1
-
Weekly BI 836880 in Patients With Advanced Solid Tumors
NCT02689505 ·Status: COMPLETED ·Phase: PHASE1
-
Oncolytic Virus (OVV-01) Injection in the Treatment of Patients With Advanced Solid Tumors
NCT04787003 ·Status: UNKNOWN ·Phase: PHASE1
-
BI 6727 Administered Intravenously Every 3 Weeks in Patients With Solid Tumours
NCT02273388 ·Status: COMPLETED ·Phase: PHASE1
-
A Trial of SHR-7787 Injection Combined With Other Anti-tumor Drugs in Patients With Malignant Solid Tumors
NCT07268040 ·Status: RECRUITING ·Phase: PHASE2
-
A Study of Felmetatug Vedotin/SGN-B7H4V in Advanced Solid Tumors
NCT05194072 ·Status: TERMINATED ·Phase: PHASE1
-
Efficacy and Safety Study of Tisotumab Vedotin for Patients With Solid Tumors
NCT03485209 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
A Study of KC1036 in Patients with Advanced Solid Tumors
NCT04387916 ·Status: RECRUITING ·Phase: PHASE1
-
Safety, Pharmacokinetics, and Antitumor Activity of BGB-B167 Alone and in Combination With Tislelizumab (BGB-A317) in Participants With Advanced Solid Tumors
NCT05494762 ·Status: TERMINATED ·Phase: PHASE1
-
Dose-Escalation and Dose-Expansion Study of BSI-082 Monotherapy and Combined Therapy in Patients With Advanced or Metastatic Solid Tumors
NCT07086768 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1
-
A Study of BI 3810944 in Patients With Advanced Cancer
NCT07224425 ·Status: RECRUITING ·Phase: PHASE1
-
A Trial to Find the Safe Dose for BI 905681 in Patients With Incurable Tumours or Tumours That Have Spread
NCT04147247 ·Status: COMPLETED ·Phase: PHASE1
-
JMT106 Injection in the Treatment of Advanced Solid Tumors
NCT07275073 ·Status: RECRUITING ·Phase: PHASE1
-
A Study to Evaluate INCA036873 in Participants With Advanced Solid Tumors and Hematological Malignancies
NCT07195916 ·Status: RECRUITING ·Phase: PHASE1
-
A Study of Sigvotatug Vedotin in Advanced Solid Tumors
NCT04389632 ·Status: RECRUITING ·Phase: PHASE1
-
A Trial of SHR-4849 Combined With Other Antitumor Drugs in Patients With Malignant Solid Tumors
NCT07028281 ·Status: RECRUITING ·Phase: PHASE2
-
A Study of BA1202 in Patients With Advanced Solid Tumors
NCT05909241 ·Status: RECRUITING ·Phase: PHASE1
-
A Clinical Study to Evaluate the Safety of VIB305 in Patients With Advanced Solid Tumors
NCT07222969 ·Status: RECRUITING ·Phase: PHASE1/PHASE2