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Trial of Aldosterone-hybrid SteRoid for Guiding curablE Treatment of Primary Aldosteronism (TARGET-PA)

NCT07297745 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 120

Last updated 2026-01-09

No results posted yet for this study

Summary

The goal of this project is to improve the diagnostic pathway for patients with primary aldosteronism, by validating non-invasive biomarkers coupled with routine computed tomography imaging. The aim is to reduce reliance on invasive procedures, shorten diagnostic timelines, and enhance accessibility to definitive diagnosis and treatment globally.

Conditions

  • Hyperaldosteronism; Primary
  • Primary Aldosteronism Due to Aldosterone Producing Adenoma

Interventions

DIAGNOSTIC_TEST

Hybrid hormones

Participants will have a baseline blood sample taken so the investigators can measure the adrenal steroid biomarkers 18-oxocortisol, 18-hydroxylcortisol and other steroids. The collected plasma or serum will then be analyzed in the laboratory using validated methods, such as liquid chromatography-tandem mass spectrometry (LC-MS/MS), to determine the levels of these biomarkers.

Sponsors & Collaborators

  • Singapore General Hospital

    collaborator OTHER

  • Sengkang General Hospital

    collaborator OTHER

  • National University Hospital, Singapore

    collaborator OTHER

  • Changi General Hospital

    lead OTHER

Principal Investigators

  • Troy Puar, FRCP, PhD · Changi General Hospital

Study Design

Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
21 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-01-15
Primary Completion
2029-12-31
Completion
2029-12-31

Countries

  • Singapore

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07297745 on ClinicalTrials.gov