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Post-Endodontic Pain According to Menstrual Cycle Phases

NCT07291518 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 99

Last updated 2025-12-26

No results posted yet for this study

Summary

This study aimed to evaluate whether the phase of the menstrual cycle affects pain after root canal treatment. A total of 99 patients (72 females and 27 males) who needed root canal treatment in lower molar teeth were included. Female participants were grouped according to their menstrual cycle phase: menstrual, proliferative, and secretory. All patients received the same endodontic treatment procedure under local anesthesia. Postoperative pain intensity was recorded using a Visual Analog Scale (VAS) at 8 hours, 8-24 hours, 24-48 hours, and 48-72 hours after treatment. Analgesic (ibuprofen) use was also recorded. The results showed that women in the menstrual and secretory phases experienced higher pain levels than men, while pain levels in the proliferative phase were similar to those in men. The findings suggest that the menstrual cycle phase may influence short-term pain perception after root canal treatment.

Conditions

  • Root Canal Treatment

Interventions

PROCEDURE

root canal treathment

All participants underwent standard root canal treatment under local anesthesia and rubber dam isolation. Root canals were prepared using ProTaper Next rotary files, irrigated with 2.5% sodium hypochlorite and 17% EDTA, dried with paper points, and filled using a sealant and gutta-percha. The teeth were then restored coronally with composite resin. Postoperative pain and analgesic use were monitored for 72 hours to assess the influence of menstrual cycle phase on pain perception. This standardized procedure ensures consistency across participants and allows comparisons between menstrual phases and between male patients.

Sponsors & Collaborators

  • Ahter Sanal Cikman

    lead OTHER

Principal Investigators

  • Merve Çoban Öksüzer · pamukkale univercity

  • Ömer Hatipoğlu · recep tayyip erdoğan univercity

  • Fatma Pertek Hatipoğlu · recep tayyip erdoğan univercity

  • ahter şanal çıkman · recep tayyip erdoğan univercity

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-09-01
Primary Completion
2025-01-15
Completion
2025-01-30

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07291518 on ClinicalTrials.gov