Post-Intensive Care Syndrome - Multicentre Prospective Registry Database of the DACH Region

Summary

Post-Intensive Care Syndrome (PICS) refers to long-term cognitive, physical, and psychological impairments that can arise after intensive care treatment. These symptoms may begin within 24 hours of ICU admission and persist for years. Affected patients and their families (PICS-F) face significant burdens, with up to 94% of relatives impacted. Given its high prevalence and socioeconomic impact, this prospective registry study aims to identify risk factors and long-term consequences of PICS and PICS-F.

The study consists of six modules, starting with data collection during ICU stays and continuing with follow-ups at various intervals post-discharge (up to five years). The primary goal is to investigate diagnostic and therapeutic strategies, while secondary objectives include identifying risk factors, determining impairment severity, and exploring biological mechanisms. Standardized questionnaires and biological samples (blood) are used for data collection.

Conditions

• PICS
• PICS-F

Sponsors & Collaborators

• Charite University, Berlin, Germany

  collaborator OTHER

• University of Wuerzburg

  collaborator OTHER

• University Hospital Augsburg

  collaborator OTHER

• Medical University of Vienna

  lead OTHER

Principal Investigators

• Stefan J Schaller, MD · Medical University of Vieanna

• Bjoern Weiss, MD · Charite University, Berlin, Germany

• Claudia Denke, Dr. · Charite University, Berlin, Germany

• Patrick Meybohm, MD · Wuerzburg University Hospital

• Philipp Simon, MD · Universitätsklinikum Augsburg

• Claudia Spies, MD · Charite University, Berlin, Germany

• Christian Stoppe, MD · Wuerzburg University Hospital

• Manfred Weiss, MD · Universitätsklinikum Augsburg

• Marion Wiegele, MD · Medical University of Vienna

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2026-02-04

Primary Completion

2030-11-01

Completion

2035-11-01

Countries

• Austria
• Germany

Study Locations