DALY II Japan/MB-CART2019.1 for DLBCL
NCT07288879 · Status: RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 31
Last updated 2026-01-08
Summary
DALY II Japan is a phase II, multi-center, single arm study to evaluate the efficacy, safety, and pharmacokinetics of zamtocabtagene autoleucel (MB-CART2019.1) in patients with relapsed and/or refractory diffuse large B cell lymphoma (DLBCL) after receiving at least two lines of therapy.
Conditions
- DLBCL - Diffuse Large B Cell Lymphoma
- CAR T Cell Therapy
Interventions
- BIOLOGICAL
-
MB-CART2019.1
CAR T cell therapy
Sponsors & Collaborators
-
Miltenyi Biomedicine GmbH
lead INDUSTRY
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2025-12-11
- Primary Completion
- 2027-01-31
- Completion
- 2028-12-31
Countries
- Japan
Study Locations
More Related Trials
-
A Phase I Trial to Establish the Safety and Maximum Tolerated Dose of High-affinity Autologous BCMA-targeting Chimeric Antigen Receptor (CAR) T-cells in Patients With Relapsed and Refractory B-cell Malignancies
NCT05836896 ·Status: RECRUITING ·Phase: PHASE1
-
The Study of Anti-CD19 CAR NK Cells in the Treatment of Relapsed/Refractory Diffuse Large B Cell Lymphoma
NCT05673447 ·Status: UNKNOWN ·Phase: EARLY_PHASE1
-
Safety, Efficacy and Pharmacokinetics of XKDCT023 in DLBCL
NCT05269914 ·Status: UNKNOWN ·Phase: NA
-
ThisCART19A for B-NHL Relapsed After Auto-CAR T
NCT05691153 ·Status: RECRUITING ·Phase: PHASE1
-
CD19-targeted CAR T Cells for Relapsed and Refractory (R/R) Mantle Cell Lymphoma
NCT04718883 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
L218CAR19 in Patients With Relapsed/Refractory B-cell Lymphoma
NCT06478381 ·Status: RECRUITING ·Phase: PHASE1
-
Study Evaluating the Safety and Efficacy of JWCAR029 in Adult Subjects With Relapsed and Refractory B-cell Non-Hodgkin Lymphoma
NCT03355859 ·Status: UNKNOWN ·Phase: PHASE1
-
A Study to Evaluate the Safety and Clinical Activity of GF- CART01 (CD20/19 CAR T Cell) in Subjects With Relapsed or Refractory B-Cell Hematological Malignancies
NCT06703892 ·Status: RECRUITING ·Phase: PHASE1
-
Dual Target CAR-T Cells in B-cell Lymphoma
NCT04723914 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
CD19/CD22 Bispecific CAR-T Cell Therapy for Relapsed/Refractory B-cell Lymphoma or Acute Lymphoblastic Leukemia
NCT06081478 ·Status: RECRUITING ·Phase: PHASE2
-
Study of T Cells Targeting CD19/BCMA (CART-19/BCMA) for High Risk Multiple Myeloma Followed With Auto-HSCT
NCT03455972 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1/PHASE2
-
Treatment of Relapsed and/or Chemotherapy Refractory B-cell Malignancy by CART19
NCT01864889 ·Status: UNKNOWN ·Phase: NA
-
Sequential Infusion of Anti-CD19 and Anti-CD20 CAR-T Cells Against Relapsed and Refractory B-cell Lymphoma
NCT03207178 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Research Development(RD)13-02 Chimeric Antigen Receptor(CAR) -T Cell Injection for Patients With r/r Cluster Of Differentiation 7(CD7)+ T-Acute Lymphoblastic Leukemia(ALL)/T-Lymphoblastic Lymphoma(LBL) /Acute Myelogenous Leukemia(AML)
NCT05907603 ·Status: COMPLETED ·Phase: EARLY_PHASE1
-
Sequential Low-dose Decitabine With PD-1/CD28 CD19 CAR-T in Relapsed or Refractory B-cell Lymphoma
NCT04850560 ·Status: UNKNOWN ·Phase: PHASE1
-
CD19-targeted CAR T Cells for Relapsed and Refractory (R/R) Non-Hodgkins Lymphoma
NCT04089215 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Exploratory Clinical Study of CD19-targeted CAR-T and CAR-DC in the Treatment of Relapsed and Refractory B-cell Lymphoma
NCT05585996 ·Status: RECRUITING ·Phase: PHASE1
-
Safety, Efficacy and Pharmacokinetics of ThisCART19A in Patients With Refractory or Relapsed B Cell Lymphoma
NCT05535673 ·Status: UNKNOWN ·Phase: PHASE1
-
Clinical Study of C402-CD19-CAR Treatment in Subjects With Relapsed or Refractory B-cell Lymphoma
NCT06830031 ·Status: RECRUITING ·Phase: PHASE1
-
CART-19 Cells For MRD Positive CD19+ ALL
NCT03027739 ·Status: UNKNOWN ·Phase: PHASE2/PHASE3
-
CD79b CAR-T Cell Therapy for Patients With Relapsed and/or Refractory Acute Lymphoblastic Leukemia and B-cell Non-Hodgkin's Lymphoma
NCT04609241 ·Status: NOT_YET_RECRUITING ·Phase: EARLY_PHASE1
-
A Phase I Dose Finding Study of MB-CART2219.1
NCT07108868 ·Status: RECRUITING ·Phase: PHASE1
-
Dual Specificity CD19 and CD22 CAR-T Cell Immunotherapy for CD19+CD22+ Relapsed and Refractory Lymphoma
NCT03468153 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Clinical Study of Multi-targeted CAR-T Therapy in Patients With Relapsed/Refractory B-Cell Lymphoma
NCT07093086 ·Status: WITHDRAWN ·Phase: PHASE1
-
Study Evaluating the Efficacy and Safety With CAR-T for Recurrent or Refractory Diffuse Large B Cell Lymphoma
NCT02728882 ·Status: UNKNOWN ·Phase: NA