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Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment Delays

NCT07283939 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 420

Last updated 2026-05-11

No results posted yet for this study

Summary

This study seeks to learn whether using the PAGODA algorithm to guide chemotherapy dosing will lower the chance of unplanned delays during chemotherapy for cancer in the gastrointestinal system compared to usual care.

Conditions

  • Ampulla of Vater Carcinoma
  • Appendix Carcinoma
  • Carcinoma of Unknown Primary With Gastrointestinal Profile
  • Colon Carcinoma
  • Esophageal Carcinoma
  • Gastric Carcinoma
  • Gastroesophageal Junction Carcinoma
  • Malignant Digestive System Neoplasm
  • Rectal Carcinoma
  • Small Intestinal Carcinoma

Interventions

OTHER

PAGODA algorithm

use PAGODA algorithm to determine chemotherapy delays and dose modifications

DRUG

Oxaliplatin

Given IV

DRUG

Folinic Acid

Given IV

DRUG

Fluorouracil

Given IV

Sponsors & Collaborators

Principal Investigators

  • Gabriel A. Brooks, MD, MPH · Alliance for Clinical Trials in Oncology

Study Design

Allocation
RANDOMIZED
Purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-02-13
Primary Completion
2030-05-01
Completion
2030-05-02

Countries

  • United States
  • Puerto Rico

Study Locations

More Related Trials

Entities

Drugs
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07283939 on ClinicalTrials.gov