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Implications of Post-Operative Irrigation Fluid's Osmolarity on the Recurrence of Non-Muscle Invasive Bladder Cancer Following Transurethral Resection

NCT07279792 · Status: COMPLETED · Phase: PHASE2/PHASE3 · Type: INTERVENTIONAL · Enrollment: 150

Last updated 2025-12-29

No results posted yet for this study

Summary

This randomized controlled trial will evaluate the efficacy of three bladder irrigation solutions - distilled water (DW), normal saline (NS), and hypertonic saline (HS) - as continuous bladder irrigation (CBI) following transurethral resection of non-muscle invasive bladder cancer (NMIBC). Short term (6 months) recurrence and progression free survival are mainly evaluated.

Conditions

  • Bladder (Urothelial, Transitional Cell) Cancer
  • Nonmuscle Invasive Bladder Cancer
  • Irrigation
  • Hypertonic Saline
  • Normal Saline
  • Distilled Water

Interventions

DRUG

Continuous Bladder Irrigation with distilled water

Continuous Bladder Irrigation with distilled water post non muscle invasive bladder cancer urethral resection by endoscopy

DRUG

Continuous Bladder Irrigation with normal saline

Continuous Bladder Irrigation with normal saline post non muscle invasive bladder cancer urethral resection by endoscopy

DRUG

Continuous Bladder Irrigation with hypertonic saline

Continuous Bladder Irrigation with hypertonic saline post non muscle invasive bladder cancer urethral resection by endoscopy

Sponsors & Collaborators

  • Ain Shams University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-10-01
Primary Completion
2025-08-01
Completion
2025-09-01

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07279792 on ClinicalTrials.gov