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Platelet Aggregation in the Diagnosis of Acute Graft Rejection

NCT07275541 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 60

Last updated 2025-12-10

No results posted yet for this study

Summary

The study titled "Platelet Aggregation in the Diagnosis of Acute Graft Rejection" is a pilot observational study evaluating whether alterations in platelet function can serve as non-invasive markers of acute rejection in kidney transplant recipients. Platelet aggregation is assessed using optical aggregometry, flow-cytometric P-selectin (CD62-P) expression, and soluble P-selectin levels before kidney transplantation and at the time of protocol biopsies performed at 3 and 12 months after kidney transplantation. Patients with suspected graft dysfunction undergoing indication biopsy are also included. Platelet activation markers are correlated with histopathological findings, donor-specific antibodies, metabolic parameters, and clinical outcomes. The goal is to determine whether platelet activation profiles can identify acute cellular or antibody-mediated rejection and contribute to the development of a non-invasive diagnostic tool.

Conditions

  • Platelet Aggregation
  • Kidney Transplant Rejection

Sponsors & Collaborators

  • University Hospital, Martin

    lead OTHER

Principal Investigators

  • Matej Vnucak, ass prof, MD, PhD. · University Hospital Martin and Jessenius Faculty of Medicine, Comenius University

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-11-26
Primary Completion
2026-11-26
Completion
2027-11-26

Countries

  • Slovakia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07275541 on ClinicalTrials.gov