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Efficacy in Preventing Hypertrophic Scars: A Randomised Controlled Trial Comparing Chitosan Cream, Silicone Gel & Olive Oil

NCT07269093 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 120

Last updated 2026-01-02

No results posted yet for this study

Summary

The goal of this clinical trial is to compare the efficacy of three different topical applications in preventing hypertrophic scars in adults with scars healed after suturing. The main question it aims to answer is: Is Chitosan cream effective in preventing hypertrophic scars?

Researchers will compare Chitosan cream with silicone gel and olive oil to see if there is any difference in their efficacies.

Participants will be randomly assigned to three groups, with each group using a different topical application. They will be instructed to:

* apply the topical application on their scar twice a day for 8 weeks
* attend follow-up visits at 4, 12 and 24 weeks for a doctor to assess their scar and take clinical photographs
* immediately inform the researcher if they experience any side effects

Conditions

  • Hypertrophic Scars

Interventions

DEVICE

Chitosan cream

Application of Chitosan cream twice daily for 8 weeks

DEVICE

Silicone Gel

Application of silicone gel twice a day for 8 weeks

DEVICE

Olive Oil Topical Oil

Application of olive oil twice daily for 8 weeks

Sponsors & Collaborators

  • Universiti Sains Malaysia

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-12-21
Primary Completion
2026-11-30
Completion
2026-11-30

Countries

  • Malaysia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07269093 on ClinicalTrials.gov