Tirzepatide for the Treatment of Cannabis Use Disorder
NCT07265752 · Status: NOT_YET_RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 6
Last updated 2025-12-18
Summary
This is a pilot randomized cross-over trial to examine the effects of tirzepatide on cue-reactivity among individuals with cannabis use disorder.
Conditions
- Cannabis Use Disorder
Interventions
- DRUG
-
2.5mg subcutaneous injection once
- DRUG
-
Saline placebo subcutaneous injection once
Sponsors & Collaborators
-
Brigham and Women's Hospital
lead OTHER
Principal Investigators
-
Joji Suzuki · Brigham and Women's Hospital
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- QUADRUPLE
- Model
- CROSSOVER
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2026-07-01
- Primary Completion
- 2028-06-30
- Completion
- 2028-06-30
- FDA Drug
- Yes
More Related Trials
-
Treatment of Overweight Induced by Antipsychotic Medication in Young People With Autism Spectrum Disorders (ASD)
NCT01825798 ·Status: COMPLETED ·Phase: PHASE3
-
Home-based Intervention With Semaglutide Treatment Of Neuroleptica-Related Prediabetes
NCT05193578 ·Status: COMPLETED ·Phase: PHASE2
-
Effects of Intranasal Insulin on Neuroimaging Markers and Cognition in Patients With Psychotic Disorders
NCT03943537 ·Status: COMPLETED ·Phase: PHASE2
-
Efficacy and Safety Evaluation of Osilodrostat in Cushing's Disease
NCT02697734 ·Status: COMPLETED ·Phase: PHASE3
-
Glucagon-like Peptide 1 (GLP1) Receptor Agonists and Mental Health
NCT05492305 ·Status: UNKNOWN
-
The Effect of Dulaglutide as an Adjuvant Therapy on Cognitive Function in Bipolar Disorder Patients With Obesity
NCT06331286 ·Status: UNKNOWN ·Phase: NA
-
Osilodrostat in Patients With Hypertension Caused by Hypercortisolaemia Due to Cushing's Syndrome
NCT07247162 ·Status: NOT_YET_RECRUITING ·Phase: PHASE4
-
The Effect of GLP-1 Receptor Activation on Central Reward and Satiety in Obesity and Diabetes
NCT01281228 ·Status: COMPLETED ·Phase: NA
-
Does a GLP-1 Receptor Agonist Change Glucose Tolerance in Antipsychotic-treated Patients?
NCT01845259 ·Status: UNKNOWN ·Phase: PHASE2
-
Metformin for Overweight & OBese ChILdren and Adolescents With BDS Treated With SGAs
NCT02515773 ·Status: COMPLETED ·Phase: PHASE4
-
Study to Evaluate the Effects of a Cytochrome P450 2C19 Inhibitor on the Pharmacokinetics of Miricorilant
NCT05712265 ·Status: COMPLETED ·Phase: PHASE1
-
EXOMIND (BTL-699-2) for the Improvement in Willpower & Food Cravings
NCT07056036 ·Status: COMPLETED ·Phase: NA
-
Green Tea Extract for Obesity of Psychiatric Patients
NCT03548103 ·Status: COMPLETED ·Phase: NA
-
Examining the Effects of CXB722 in Neuroendocrine Stress Response in Healthy Males
NCT00814931 ·Status: COMPLETED ·Phase: PHASE1
-
Semaglutide in Comorbid Schizophrenia Spectrum Disorder and Obesity
NCT05333003 ·Status: RECRUITING ·Phase: NA
-
Safety and Efficacy of LCI699 for the Treatment of Patients With Cushing's Disease
NCT02180217 ·Status: COMPLETED ·Phase: PHASE3
-
A Study to Assess the Safety and Efficacy of Levoketoconazole in the Treatment of Endogenous Cushing's Syndrome.
NCT03277690 ·Status: COMPLETED ·Phase: PHASE3
-
Effect of Oral 6-bromotryptophan on Safety, Pharmacokinetics and Efficacy in Metabolic Syndrome Individuals
NCT05971524 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
An Open-Label Treatment Protocol to Provide Metreleptin for the Treatment of Diabetes Mellitus and/or Hypertriglyceridemia Associated With Lipodystrophy
NCT00677313 ·Status: COMPLETED ·Phase: NA
-
Does Abnormal Insulin Action in the Brain Underlie Cognitive and Metabolic Dysfunction in Schizophrenia
NCT05748990 ·Status: RECRUITING ·Phase: NA
-
Topiramate vs Metformin on Cardio-Metabolic Profile in Schizophrenia on Atypical Antipsychotics
NCT05663749 ·Status: COMPLETED ·Phase: PHASE4
-
An Open-label Trial of Metformin for Weight Control of Pediatric Patients on Antipsychotic Medications.
NCT00391261 ·Status: COMPLETED ·Phase: PHASE4
-
Effects of Herbal Products on Metabolism and Hunger
NCT00198952 ·Status: COMPLETED ·Phase: NA
-
The Therapeutic Effects of Topiramate and Metformin on Second Generation Antipsychotics-induced Obesity
NCT01384279 ·Status: COMPLETED ·Phase: NA
-
The Effects of Modafinil to Counteract the Adverse Metabolic Consequences of Sleep Restriction
NCT00895570 ·Status: COMPLETED ·Phase: NA