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Targeting Immunosuppressive Treatment for Non-infectious Uveitis Using Aqueous Humor Cytokine Profiles

NCT07262437 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 220

Last updated 2025-12-03

No results posted yet for this study

Summary

This multicenter, prospective, interventional, non-pharmacological study aims to investigate whether the intraocular cytokine profile is associated with the therapeutic response to immunosuppressive drugs in patients with non-infectious uveitis (NIU). Approximately 220 patients with NIU in at least one eye, showing inadequate response to topical or systemic corticosteroids at baseline and presenting with signs of anterior segment inflammation, will be enrolled to enhance sensitivity to laboratory assays. Aqueous humor and blood samples will be collected at baseline. Cytokine concentrations of 14 different cytokines will be measured using multiplex immunoassay techniques. Participants will receive immunosuppressive treatment based on standard clinical practice.

Conditions

  • Uveitis Posterior Non-Infectious
  • Inflammation Eye
  • Uveitis
  • Uveitis, Anterior

Interventions

PROCEDURE

to improve clinical practice in treatment of non-infective uveitis

to identify the potential correlation between cytokine profiles and systemic immunosuppressive drug.

Sponsors & Collaborators

  • IRCCS San Raffaele

    collaborator OTHER

  • University of Milan

    lead OTHER

Principal Investigators

  • Alessandro Invernizzi, MD · University of Milan

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-11-15
Primary Completion
2026-02-28
Completion
2026-07-01

Countries

  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07262437 on ClinicalTrials.gov