Xylitol Gum for Promoting Smoking Cessation

Summary

The goal of this clinical trial is to learn if 4-week xylitol gum intervention works to promote smoking cessation in daily smokers. It will also learn about the feasibility and acceptability of using xylitol gum. The main questions it aims to answer are:

（1）Does xylitol gum help to reduce cigarette consumption and promote smoking cessation?

Researchers will compare 4-week xylitol gum intervention to the brief advice to see if xylitol gum works to promote smoking cessation.

Participants in the intervention group will receive a 3-month behavioral intervention comprising a 4-week xylitol gum aligned with 12 weeks of instant reminder message support.

Conditions

• Smoking Cessation
• Health Promotion

Interventions

BEHAVIORAL

Self-help smoking cessation booklet

The self-help smoking cessation booklet includes commonly used smoking cessation strategies.

BEHAVIORAL

Brief smoking cessation advice

Brief smoking cessation advice guided by the validated AWARD model (Assess, Warning, Advice, Refer, and Do-it-again).

BEHAVIORAL

Warning leaflet

The warning leaflet contains pictorial depictions of the adverse health effects of smoking.

BEHAVIORAL

4-week xylitol gum intervention

Participants in the intervention group will receive 4 packs of xylitol gum (approximately US $2 per pack) at baseline and will be encouraged to use it when they experience cravings.

BEHAVIORAL

Instructional leaflet

The instructional leaflet includes the potential benefits of xylitol gum for smoking cessation, recommended timing and dosage for use, and appropriate disposal of used gum.

BEHAVIORAL

12-week instant message support

Approximately 24 reminder messages (two per week), developed based on the Love and Care Approach framework, will be delivered over the 12-week period to reinforce motivation and adherence.

Sponsors & Collaborators

• The University of Hong Kong

  lead OTHER

Principal Investigators

• Man Ping Wang, PhD · The University of Hong Kong

Study Design

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2025-11-24

Primary Completion

2026-02-28

Completion

2026-09-30

Countries

• Hong Kong

Study Locations