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15 vs 45 Minute Pringle Maneuver in Liver Cancer Resection: Randomized Noninferiority Trial

NCT07237204 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 600

Last updated 2025-11-19

No results posted yet for this study

Summary

The goal of this clinical trial is to evaluate the safety of two durations of the Pringle maneuver in adults undergoing elective liver resection for malignant tumors. The main questions it aims to answer are:

Is the incidence of post-hepatectomy liver failure different between 15-minute and 45-minute Pringle maneuver durations?

* Do the durations differ in operative time or intraoperative blood loss?
* Researchers will compare patients randomized 1:1 to 15 minutes vs 45 minutes of Pringle clamping to see if outcomes are non-inferior between groups.

Participants will:

* Undergo standard oncologic hepatectomy with the assigned Pringle duration.
* Receive routine perioperative assessments, including laboratory tests and clinical evaluations.
* Attend follow-up visits at approximately 6 months, 1 year, and 3 years after surgery.

Conditions

  • Liver Cancer, Adult
  • Metastases to Liver
  • Liver Malignant Tumors

Interventions

PROCEDURE

Pringle manouver

The Pringle maneuver involves temporary clamping of the hepatic pedicle during liver resection to reduce blood loss during parenchymal transection.

Sponsors & Collaborators

  • Medical University of Warsaw

    lead OTHER

Principal Investigators

  • Emilia Kruk, MD · Medical University of Warsaw

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-12-01
Primary Completion
2028-11-01
Completion
2030-11-01

Countries

  • Poland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07237204 on ClinicalTrials.gov